Squamous cell carcinoma of the lung
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Squamous cell carcinoma of the lung, also lung squamous cell carcinoma, is a common malignant lung tumour that is associated with smoking.
General
- Strong association with smoking.
- May be treated with surgery.
Gross
- Usually centrally located, i.e. large airways.
Microscopic
Features:
- Central nucleus.
- Dense appearing cytoplasm, usu. eosinophilic.
- +/-Small nucleolus.
DDx:
- Metastatic squamous cell carcinoma.
- Adenocarcinoma of the lung.
- Non-small cell lung carcinoma - diagnosis should be avoid if possible.
IHC
- p40 +ve.[1]
- p63 +ve -- less specific.
- TTF-1 -ve.
- Positive in adenocarcinoma.
- Calponin -ve.
- CK5/6 +ve.
See also
References
- ↑ Bishop, JA.; Teruya-Feldstein, J.; Westra, WH.; Pelosi, G.; Travis, WD.; Rekhtman, N. (Mar 2012). "p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma.". Mod Pathol 25 (3): 405-15. doi:10.1038/modpathol.2011.173. PMID 22056955.