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Difference between revisions of "Spitz nevus"
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| ClinDDx = [[melanoma]], other [[melanocytic lesions]] | | ClinDDx = [[melanoma]], other [[melanocytic lesions]] | ||
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'''Spitz nevus''', also known as '''epithelioid and spindle | '''Spitz nevus''', also known as '''epithelioid and spindle cell nevus''', is an uncommon [[melanocytic lesion]] that can be difficult to differentiate from [[malignant melanoma]]. | ||
==General== | ==General== | ||
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*+/-[[Acanthosis]] (thick stratum spinosum). | *+/-[[Acanthosis]] (thick stratum spinosum). | ||
*Kamino bodies (also written ''Camino bodies'') - dense eosinophilic bodies.<ref name=PMC2797485>{{Cite journal | last1 = Kirkwood | first1 = John M. | last2 = Jukic | first2 = Drazen | last3 = Averbook | first3 = Bruce J. | last4 = Sender | first4 = Leonard S. | title = Melanoma in Pediatric, Adolescent, and Young Adult Patients | journal = Semin Oncol. | volume = 36 | issue = 5 | pages = 419-31 | month = October | year = 2009 | doi = | PMID = | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797485/?tool=pmcentrez |PMC = 2797485 }}</ref> | *Kamino bodies (also written ''Camino bodies'') - dense eosinophilic bodies.<ref name=PMC2797485>{{Cite journal | last1 = Kirkwood | first1 = John M. | last2 = Jukic | first2 = Drazen | last3 = Averbook | first3 = Bruce J. | last4 = Sender | first4 = Leonard S. | title = Melanoma in Pediatric, Adolescent, and Young Adult Patients | journal = Semin Oncol. | volume = 36 | issue = 5 | pages = 419-31 | month = October | year = 2009 | doi = | PMID = | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797485/?tool=pmcentrez |PMC = 2797485 }}</ref> | ||
**Kamino bodies are rare in melanoma. | **Kamino bodies are rare in melanoma. | ||
**Pathogenesis uncertain - probably represent aggregates of basement membrane material.<ref name=pmid9855349>{{Cite journal | last1 = Skelton | first1 = HG. | last2 = Miller | first2 = ML. | last3 = Lupton | first3 = GP. | last4 = Smith | first4 = KJ. | title = Eosinophilic globules in spindle cell and epithelioid cell nevi: composition and possible origin. | journal = Am J Dermatopathol | volume = 20 | issue = 6 | pages = 547-50 | month = Dec | year = 1998 | doi = | PMID = 9855349 }}</ref> | |||
***The classic teachng is Kamino bodies are apoptotic cells; however, this is disputed by evidence.<ref name=pmid9855350>{{Cite journal | last1 = Wesselmann | first1 = U. | last2 = Becker | first2 = LR. | last3 = Bröcker | first3 = EB. | last4 = LeBoit | first4 = PE. | last5 = Bastian | first5 = BC. | title = Eosinophilic globules in spitz nevi: no evidence for apoptosis. | journal = Am J Dermatopathol | volume = 20 | issue = 6 | pages = 551-4 | month = Dec | year = 1998 | doi = | PMID = 9855350 }}</ref> | |||
Notes: | Notes: | ||
*'''Never''' in the setting of [[solar elastosis]].<ref>Jakubovic, H. 16 July 2010.</ref> | *'''Never''' in the setting of [[solar elastosis]].<ref>Jakubovic, H. 16 July 2010.</ref> | ||