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Difference between revisions of "Small round cell tumours"
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Small round cell tumours (view source)
Revision as of 16:38, 28 February 2011
, 16:38, 28 February 2011→Tabular comparison: wikify
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(→Tabular comparison: wikify) |
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| '''Key [[IHC]] / <br>special stains''' | | '''Key [[IHC]] / <br>special stains''' | ||
|- | |- | ||
| Hepatoblastoma | | [[Hepatoblastoma]] | ||
| fetal hepatocytes (~ 1:3 NC ratio, eosinophilic cytoplasm) | | fetal hepatocytes (~ 1:3 NC ratio, eosinophilic cytoplasm) | ||
| liver | | liver lesion, usu. < 3 years old | ||
| AFP | | AFP | ||
|- | |- | ||
| Neuroblastoma | | [[Neuroblastoma]] | ||
| nests, thin fibrovascular septae, lymphocytes, ganglion-like cells (prominent nucleolus), neurophil (eosinophilic, fluffy, finely vacuolated) | | nests, thin fibrovascular septae, lymphocytes, ganglion-like cells (prominent nucleolus), neurophil (eosinophilic, fluffy, finely vacuolated) | ||
| adrenal gland, sympathetic chain; usu. < 3 years old | | adrenal gland, sympathetic chain; usu. < 3 years old | ||
| NB-84+, NSE+, S100- | | NB-84+, NSE+, S100- | ||
|- | |- | ||
| Nephroblastoma (Wilms tumour) | | [[Nephroblastoma]] (Wilms tumour) | ||
| triphasic - (1) blue cells (blastema), (2) spindle cells (stroma), (3) tubular structures (epithelial) | | triphasic - (1) blue cells (blastema), (2) spindle cells (stroma), (3) tubular structures (epithelial) | ||
| kidney lesion, various syndromes | | kidney lesion, various syndromes | ||
| WT-1+ | | WT-1+ | ||
|- | |- | ||
| Retinoblastoma | | [[Retinoblastoma]] | ||
| Flexner-Wintersteiner rosette (rosette with empty centre (donut hole))<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref> | | Flexner-Wintersteiner rosette (rosette with empty centre (donut hole))<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref> | ||
| eye lesion; +/-RB1 gene mutations (familial) | | eye lesion; +/-RB1 gene mutations (familial) | ||
| | | | ||
|- | |- | ||
| Medulloblastoma | | [[Medulloblastoma]] | ||
| Homer-Wright rosettes (rosette with a meshwork of fibers (neuropil) at the centre)<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref> | | Homer-Wright rosettes (rosette with a meshwork of fibers (neuropil) at the centre)<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref> | ||
| +/-nevoid basal cell carcinoma syndrome | | +/-nevoid basal cell carcinoma syndrome | ||
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| "DAM" = desmin, actin, myogenin | | "DAM" = desmin, actin, myogenin | ||
|- | |- | ||
| Desmoplastic small round cell tumour (DSRCT) | | [[Desmoplastic small round cell tumour]] (DSRCT) | ||
| nests with "jigsaw" border | | nests with "jigsaw" border | ||
| peritoneum (abdomen or plevis); male > female; locally invasive | | peritoneum (abdomen or plevis); male > female; locally invasive | ||
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| synaptophysin, chromogranin, CD56, keratins | | synaptophysin, chromogranin, CD56, keratins | ||
|- | |- | ||
| Lymphoma (large cell) | | [[Lymphoma]] (large cell) | ||
| dyscohesive cells, ~2x normal (resting) lymphocyte, nucleolus | | dyscohesive cells, ~2x normal (resting) lymphocyte, nucleolus | ||
| lymphadenopathy (???) | | lymphadenopathy (???) | ||