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Difference between revisions of "Small cell carcinoma of the urinary bladder"
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Small cell carcinoma of the urinary bladder (view source)
Revision as of 21:25, 17 May 2022
, 21:25, 17 May 2022→Microscopic
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| Caption = [[Small cell carcinoma]] of the urinary bladder. [[H&E stain]]. | | Caption = [[Small cell carcinoma]] of the urinary bladder. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = | | Micro = small cohesive cells with scant cytoplasm, nuclear moulding | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[small cell carcinoma of the prostate gland]], [[lymphoma]] (large cell), other [[small round blue cell tumours]] | | LMDDx = [[small cell carcinoma of the prostate gland]], [[lymphoma]] (large cell), other [[small round blue cell tumours]], [[urothelial carcinoma]] with a small cell carcinoma component | ||
| Stains = [[pankeratin]] +ve, chromogranin +ve, synaptophysin +ve, [[CD56]] +ve | | Stains = [[pankeratin]] +ve, chromogranin +ve, synaptophysin +ve, [[CD56]] +ve | ||
| IHC = | | IHC = | ||
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==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
* | *Cohesive small cells (~2x resting lymphocytes) with scant cytoplasm - see ''[[small cell carcinoma]]''. | ||
*+/-Nuclear moulding. | |||
*If mixed histology with urothelial carcinoma, ''small cell carcinoma'' component must be majority of tumour; otherwise classified as ''urothelial carcinoma with small cell carcinoma component''.<ref>{{Ref WHOGU2016|117-8}}</ref> | |||
Note: | Note: | ||
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DDx: | DDx: | ||
*[[Urothelial carcinoma]] with a small cell carcinoma component | |||
*[[Small cell carcinoma of the prostate gland]]. | *[[Small cell carcinoma of the prostate gland]]. | ||
*[[Lymphoma]], large cell. | *[[Lymphoma]], large cell. | ||
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*Synaptophysin +ve. | *Synaptophysin +ve. | ||
*[[CD56]] +ve. | *[[CD56]] +ve. | ||
*TTF-1 +ve/-ve. | |||
==Sign out== | ==Sign out== | ||
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Comment: | Comment: | ||
The tumour consists of cohesive | The tumour consists of cohesive, small blue cells with nuclear moulding and necrosis. There is no definite urothelial differentiation, and no other differentiation to suggest a particular primary site. | ||
The tumour stains as follows: | The tumour stains as follows: | ||