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Difference between revisions of "Small cell carcinoma of the urinary bladder"
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Small cell carcinoma of the urinary bladder (view source)
Revision as of 21:25, 17 May 2022
, 21:25, 17 May 2022→Microscopic
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| Caption = [[Small cell carcinoma]] of the urinary bladder. [[H&E stain]]. | | Caption = [[Small cell carcinoma]] of the urinary bladder. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = | | Micro = small cohesive cells with scant cytoplasm, nuclear moulding | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[small cell carcinoma of the prostate gland]], [[lymphoma]] (large cell), other [[small round blue cell tumours]] | | LMDDx = [[small cell carcinoma of the prostate gland]], [[lymphoma]] (large cell), other [[small round blue cell tumours]], [[urothelial carcinoma]] with a small cell carcinoma component | ||
| Stains = [[pankeratin]] +ve, chromogranin +ve, synaptophysin +ve, [[CD56]] +ve | | Stains = [[pankeratin]] +ve, chromogranin +ve, synaptophysin +ve, [[CD56]] +ve | ||
| IHC = | | IHC = | ||
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==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
* | *Cohesive small cells (~2x resting lymphocytes) with scant cytoplasm - see ''[[small cell carcinoma]]''. | ||
*+/-Nuclear moulding. | |||
*If mixed histology with urothelial carcinoma, ''small cell carcinoma'' component must be majority of tumour; otherwise classified as ''urothelial carcinoma with small cell carcinoma component''.<ref>{{Ref WHOGU2016|117-8}}</ref> | |||
Note: | Note: | ||
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DDx: | DDx: | ||
*[[Urothelial carcinoma]] with a small cell carcinoma component | |||
*[[Small cell carcinoma of the prostate gland]]. | *[[Small cell carcinoma of the prostate gland]]. | ||
*[[Lymphoma]], large cell. | *[[Lymphoma]], large cell. | ||
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*Synaptophysin +ve. | *Synaptophysin +ve. | ||
*[[CD56]] +ve. | *[[CD56]] +ve. | ||
*TTF-1 +ve/-ve. | |||
==Sign out== | |||
<pre> | |||
Urinary Bladder Tumour, Transurethral Resection: | |||
- SMALL CELL CARCINOMA, invades muscularis propria, see comment. | |||
-- Please see synoptic report. | |||
Comment: | |||
The tumour consists of cohesive, small blue cells with nuclear moulding and necrosis. There is no definite urothelial differentiation, and no other differentiation to suggest a particular primary site. | |||
The tumour stains as follows: | |||
POSITIVE: CK7 (dot-like moderate, diffuse), chromogranin A (moderate, diffuse), synaptophysin (strong, diffuse), TTF-1 (strong, diffuse). | |||
NEGATIVE: CK20, CD45 (lymphocytes in background), CD20, PSA, p63 (marks benign urothelium). | |||
PROLIFERATION (Ki-67): >90%. | |||
Small cell carcinoma of the urinary bladder is the main consideration, based the anatomical site of the specimen. The findings above should be considered in the context of the imaging and clinical history. | |||
</pre> | |||
==See also== | ==See also== | ||