Difference between revisions of "Sex cord tumour with annular tubules"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Sex_cord_tumour_with_annular_tubules_-_2_-_very_high_mag.jpg
| Width      =
| Caption    = SCTAT. [[H&E stain]].
| Synonyms  =
| Micro      = well-circumscribed nests of cells with nuclei at the periphery, annular tubules (ring-shaped tubules) with dense hyaline material
| Subtypes  = benign, malignant (very rare)
| LMDDx      = [[Sertoli-Leydig tumour]], [[granulosa cell tumour]], [[Brenner tumour]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[ovary]] - see ''[[ovarian tumours]]''
| Assdx      =
| Syndromes  = [[Peutz-Jeghers syndrome]]
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = usually good (benign)
| Other      =
| ClinDDx    = ovarian tumour
| Tx        =
}}
'''Sex cord tumour with annular tubules''', abbreviated '''SCTAT''', is an uncommon sex cord tumour.
'''Sex cord tumour with annular tubules''', abbreviated '''SCTAT''', is an uncommon sex cord tumour.


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DDx:
DDx:
*Sertoli-Leydig tumour - has double palisading with overlap of the layers.
*[[Sertoli-Leydig tumour]] - has double palisading with overlap of the layers.
*[[Granulosa cell tumour]] - have Call-Exner bodies, which don't have a well-defined/solid content.
*[[Granulosa cell tumour]] - have Call-Exner bodies, which don't have a well-defined/solid content.
*[[Brenner tumour]] - [[coffee-bean nuclei]].
*[[Brenner tumour]] - [[coffee-bean nuclei]].

Revision as of 15:28, 11 January 2014

Sex cord tumour with annular tubules
Diagnosis in short

SCTAT. H&E stain.
LM well-circumscribed nests of cells with nuclei at the periphery, annular tubules (ring-shaped tubules) with dense hyaline material
Subtypes benign, malignant (very rare)
LM DDx Sertoli-Leydig tumour, granulosa cell tumour, Brenner tumour
Site ovary - see ovarian tumours
Syndromes Peutz-Jeghers syndrome
Prevalence uncommon
Prognosis usually good (benign)
Clin. DDx ovarian tumour

Sex cord tumour with annular tubules, abbreviated SCTAT, is an uncommon sex cord tumour.

It is not sex cord tumour with angulated tubules.

General

  • Associated with Peutz-Jeghers syndrome.[1]
    • Large tumours more likely sporadic.
    • Small tumours more likely Peutz-Jeghers syndrome and incidental.
  • Usually benign.
    • Malignant cases reported.[2]

Microscopic

Features:

  • Well-circumscribed nests of cells with nuclei at the periphery.
  • Annular tubules (ring-shaped tubules) with dense hyaline material.

Notes:

DDx:

Images

www:

  • SCTAT - intermed. mag. (WC)

  • SCTAT - high mag. (WC)

  • SCTAT - very high mag. (WC)

  • SCTAT - very high mag. (WC)

See also

References

  1. ↑ Purohit, RC.; Alam, SZ. (Mar 1980). "Sex cord tumour of the ovary with annular tubules (SCTAT).". Histopathology 4 (2): 147-54. PMID 7358344.
  2. ↑ Lele, SM.; Sawh, RN.; Zaharopoulos, P.; Adesokan, A.; Smith, M.; Linhart, JM.; Arrastia, CD.; Krigman, HR. (Apr 2000). "Malignant ovarian sex cord tumor with annular tubules in a patient with Peutz-Jeghers syndrome: a case report.". Mod Pathol 13 (4): 466-70. doi:10.1038/modpathol.3880079. PMID 10786816.
  3. ↑ URL: http://dictionary.reference.com/browse/annular. Accessed on: 6 August 2011.
  4. ↑ Young, RH.; Welch, WR.; Dickersin, GR.; Scully, RE. (Oct 1982). "Ovarian sex cord tumor with annular tubules: review of 74 cases including 27 with Peutz-Jeghers syndrome and four with adenoma malignum of the cervix.". Cancer 50 (7): 1384-402. PMID 7104978.
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