Difference between revisions of "Serous carcinoma of the ovary"

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#redirect [[Ovarian_tumours#Serous_carcinoma_of_the_ovary]]
'''Serous carcinoma of the ovary''', also '''ovarian serous carcinoma''', is relatively common malignant [[ovarian tumour]].
 
==General==
*Most common malignant ovarian tumour in the eldery.
*Poor prognosis.
 
==Microscopic==
Features:
*Marked nuclear pleomorphism:
**Variation in size - usually marked.
**Variation in staining.
**Variation in shape.
*Prominent nucleolus - '''key feature'''.
*Eccentric nucleus.
*Architecture:
**Solid.
**Papillary - classic.
**Glandular - uncommon.
*+/-Psammoma bodies - uncommon.
*+/-Necrosis - often extensive.
 
DDx:
*[[Clear cell carcinoma of the ovary]] - less nuclear size variation.
*[[Endometrioid carcinoma of the ovary]] - usu. lower grade.
*[[Primary peritoneal serous carcinoma]] - bulk of tumour in peritoneum, small ovarian tumour.
*Other non-ovarian serous carcinomas - ''see [[serous carcinoma]]''.
*[[Ovarian serous borderline tumour]] - mild to moderate nuclear atypia, no invasion, few mitoses.
 
===Images===
<gallery>
Image:Serous_carcinoma_cytology.jpg | Serous carcinoma - cytology. (WC)
</gallery>
 
==IHC==
*WT-1 +ve - '''key immunostain'''.<ref name=pmid18830127>{{Cite journal  | last1 = Köbel | first1 = M. | last2 = Kalloger | first2 = SE. | last3 = Carrick | first3 = J. | last4 = Huntsman | first4 = D. | last5 = Asad | first5 = H. | last6 = Oliva | first6 = E. | last7 = Ewanowich | first7 = CA. | last8 = Soslow | first8 = RA. | last9 = Gilks | first9 = CB. | title = A limited panel of immunomarkers can reliably distinguish between clear cell and high-grade serous carcinoma of the ovary. | journal = Am J Surg Pathol | volume = 33 | issue = 1 | pages = 14-21 | month = Jan | year = 2009 | doi = 10.1097/PAS.0b013e3181788546 | PMID = 18830127 }}</ref>
*CK7 +ve.
*CA-125 +ve.
*ER +ve.<ref name=pmid21164285>{{Cite journal  | last1 = DeLair | first1 = D. | last2 = Oliva | first2 = E. | last3 = Köbel | first3 = M. | last4 = Macias | first4 = A. | last5 = Gilks | first5 = CB. | last6 = Soslow | first6 = RA. | title = Morphologic spectrum of immunohistochemically characterized clear cell carcinoma of the ovary: a study of 155 cases. | journal = Am J Surg Pathol | volume = 35 | issue = 1 | pages = 36-44 | month = Jan | year = 2011 | doi = 10.1097/PAS.0b013e3181ff400e | PMID = 21164285 }}</ref>
*p53 +ve.
 
Others:
*HNF-1beta -ve.<ref>{{Cite journal  | last1 = Tsuchiya | first1 = A. | last2 = Sakamoto | first2 = M. | last3 = Yasuda | first3 = J. | last4 = Chuma | first4 = M. | last5 = Ohta | first5 = T. | last6 = Ohki | first6 = M. | last7 = Yasugi | first7 = T. | last8 = Taketani | first8 = Y. | last9 = Hirohashi | first9 = S. | title = Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1 beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma. | journal = Am J Pathol | volume = 163 | issue = 6 | pages = 2503-12 | month = Dec | year = 2003 | doi =  | PMID = 14633622 | url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892387/?tool=pubmed }}</ref><ref name=omim189907>{{OMIM|189907}}</ref>
**Usually +ve in [[clear cell carcinoma of the ovary]].
 
==See also==
*[[Ovary]].
*[[Ovarian tumours]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Ovarian tumours]]

Revision as of 22:04, 1 January 2014

Serous carcinoma of the ovary, also ovarian serous carcinoma, is relatively common malignant ovarian tumour.

General

  • Most common malignant ovarian tumour in the eldery.
  • Poor prognosis.

Microscopic

Features:

  • Marked nuclear pleomorphism:
    • Variation in size - usually marked.
    • Variation in staining.
    • Variation in shape.
  • Prominent nucleolus - key feature.
  • Eccentric nucleus.
  • Architecture:
    • Solid.
    • Papillary - classic.
    • Glandular - uncommon.
  • +/-Psammoma bodies - uncommon.
  • +/-Necrosis - often extensive.

DDx:

Images

  • Serous carcinoma - cytology. (WC)

IHC

  • WT-1 +ve - key immunostain.[1]
  • CK7 +ve.
  • CA-125 +ve.
  • ER +ve.[2]
  • p53 +ve.

Others:

See also

References

  1. ↑ Köbel, M.; Kalloger, SE.; Carrick, J.; Huntsman, D.; Asad, H.; Oliva, E.; Ewanowich, CA.; Soslow, RA. et al. (Jan 2009). "A limited panel of immunomarkers can reliably distinguish between clear cell and high-grade serous carcinoma of the ovary.". Am J Surg Pathol 33 (1): 14-21. doi:10.1097/PAS.0b013e3181788546. PMID 18830127.
  2. ↑ DeLair, D.; Oliva, E.; Köbel, M.; Macias, A.; Gilks, CB.; Soslow, RA. (Jan 2011). "Morphologic spectrum of immunohistochemically characterized clear cell carcinoma of the ovary: a study of 155 cases.". Am J Surg Pathol 35 (1): 36-44. doi:10.1097/PAS.0b013e3181ff400e. PMID 21164285.
  3. ↑ Tsuchiya, A.; Sakamoto, M.; Yasuda, J.; Chuma, M.; Ohta, T.; Ohki, M.; Yasugi, T.; Taketani, Y. et al. (Dec 2003). "Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1 beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma.". Am J Pathol 163 (6): 2503-12. PMID 14633622. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892387/?tool=pubmed.
  4. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 189907
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