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Difference between revisions of "Secretory carcinoma of the breast"
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Secretory carcinoma of the breast (view source)
Revision as of 15:16, 31 December 2019
, 15:16, 31 December 2019→See also
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = | |||
| Width = | |||
| Caption = | |||
| Synonyms = | |||
| Micro = | |||
| Subtypes = | |||
| LMDDx = [[lactational change]] | |||
| Stains = | |||
| IHC = ER -ve, PR -ve, HER2 -ve, alpha-lactalbumin +ve, S-100 +ve, polyclonal CEA +ve | |||
| EM = | |||
| Molecular = ETV6-[[NTRK3]] | |||
| IF = | |||
| Gross = | |||
| Grossing = [[breast grossing]] | |||
| Staging = [[breast cancer staging]] | |||
| Site = [[breast]] - see ''[[invasive breast cancer]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = favourable | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Secretory carcinoma of the breast''' is an uncommon form of [[invasive breast cancer]] that has an appearance similar to ''[[breast with lactational changes]]''. | '''Secretory carcinoma of the breast''' is an uncommon form of [[invasive breast cancer]] that has an appearance similar to ''[[breast with lactational changes]]''. | ||
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Characteristic translocation:<ref name=pmid22129193/> | Characteristic translocation:<ref name=pmid22129193/> | ||
*t(12;15). | *t(12;15). | ||
**ETV6-NTRK3. | **ETV6-[[NTRK3]]. | ||
Note: | Note: | ||
*This translocation is also seen in [[mammary analogue secretory carcinoma]]<ref name=pmid20410810>{{Cite journal | last1 = Skálová | first1 = A. | last2 = Vanecek | first2 = T. | last3 = Sima | first3 = R. | last4 = Laco | first4 = J. | last5 = Weinreb | first5 = I. | last6 = Perez-Ordonez | first6 = B. | last7 = Starek | first7 = I. | last8 = Geierova | first8 = M. | last9 = Simpson | first9 = RH. | title = Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. | journal = Am J Surg Pathol | volume = 34 | issue = 5 | pages = 599-608 | month = May | year = 2010 | doi = 10.1097/PAS.0b013e3181d9efcc | PMID = 20410810 }}</ref> | *This translocation is also seen in [[mammary analogue secretory carcinoma]],<ref name=pmid20410810>{{Cite journal | last1 = Skálová | first1 = A. | last2 = Vanecek | first2 = T. | last3 = Sima | first3 = R. | last4 = Laco | first4 = J. | last5 = Weinreb | first5 = I. | last6 = Perez-Ordonez | first6 = B. | last7 = Starek | first7 = I. | last8 = Geierova | first8 = M. | last9 = Simpson | first9 = RH. | title = Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. | journal = Am J Surg Pathol | volume = 34 | issue = 5 | pages = 599-608 | month = May | year = 2010 | doi = 10.1097/PAS.0b013e3181d9efcc | PMID = 20410810 }}</ref> [[congenital-infantile fibrosarcoma]] and [[mesoblastic nephroma]]. | ||
==See also== | ==See also== | ||
*[[Invasive breast cancer]]. | *[[Invasive breast cancer]]. | ||
*[[ | *[[Secretory carcinoma of the salivary gland]] (previously known as ''mammary analogue secretory carcinoma''). | ||
*[[Congenital-infantile fibrosarcoma]]. | *[[Congenital-infantile fibrosarcoma]]. | ||