Difference between revisions of "Sclerosing mucoepidermoid carcinoma with eosinophilia"

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signet ring cell
Chan 1991
        associated with chronic thyroiditis
'''Sclerosing mucoepidermoid carcinoma with eosinophilia''' is an extremely rare tumour of the [[thyroid gland]].
'''Sclerosing mucoepidermoid carcinoma with eosinophilia''' is an extremely rare tumour of the [[thyroid gland]].


==General==
==General==
*Associated withh chronic thyroiditis, e.g. [[Hashimoto's thyroiditis]].
Associated with:
*Chronic thyroiditis, e.g. [[Hashimoto's thyroiditis]].
*Papillary thyroid carcinoma.


==Microscopic==
==Microscopic==
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DDx:
DDx:
*[[Medullary thyroid carcinoma]].
*[[Medullary thyroid carcinoma]].
*[[Mucoepidermoid carcinoma of the salivary gland]].
*[[Mucoepidermoid carcinoma]] of the [[salivary gland]].


==Stains==
==Stains==
*Mucin stains +ve.
*Mucin stains +ve.
==IHC==
*TTF-1 +ve
*Thyroglobulin -ve.
*PAX8 +ve.
*Calcitonin -ve.


==Molecular==
==Molecular==

Latest revision as of 03:36, 20 March 2018

Sclerosing mucoepidermoid carcinoma with eosinophilia is an extremely rare tumour of the thyroid gland.

General

Associated with:

Microscopic

Features:

  • Mucous cells
  • Squamoid differentiation.

DDx:

Stains

  • Mucin stains +ve.

IHC

  • TTF-1 +ve
  • Thyroglobulin -ve.
  • PAX8 +ve.
  • Calcitonin -ve.

Molecular

  • Negative for MAML2 rearrangements.[1]

See also

References

  1. Shah, AA.; La Fortune, K.; Miller, C.; Mills, SE.; Baloch, Z.; LiVolsi, V.; Dacic, S.; Mahaffey, AL. et al. (Mar 2017). "Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia: a clinicopathologic and molecular analysis of a distinct entity.". Mod Pathol 30 (3): 329-339. doi:10.1038/modpathol.2016.180. PMID 27910944.