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Difference between revisions of "Sarcoidosis"
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| Micro = | | Micro = | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = fungal | | LMDDx = fungal infections, [[MAC]], [[tuberculosis]], other infections, drug reactions | ||
| Stains = AFB -ve, GMS -ve, PASD -ve | | Stains = AFB -ve, GMS -ve, PASD -ve | ||
| IHC = | | IHC = | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| IF = | | IF = | ||
| Gross = | | Gross = | ||
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| Symptoms = | | Symptoms = | ||
| Prevalence = uncommon | | Prevalence = uncommon | ||
| Bloodwork = | | Bloodwork = +/-ACE elevated | ||
| Rads = +/-bilateral hilar lymphadenopathy (very common), +/-interstitial pattern, +/- pulmonary infiltrates, +/-cystic/bullous changes | | Rads = +/-bilateral hilar lymphadenopathy (very common), +/-interstitial pattern, +/- pulmonary infiltrates, +/-cystic/bullous changes | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = | | Prognosis = | ||
| Other = | | Other = | ||
| ClinDDx = [[lymphoma]], [[metastatic carcinoma]], [[Wegener's granulomatosis]], others | | ClinDDx = [[lymphoma]], [[metastatic carcinoma]], [[Wegener's granulomatosis]], others | ||
}} | }} | ||
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==General== | ==General== | ||
*Diagnosis of exclusion - infection must be excluded. | *[[Diagnosis of exclusion]] - infection, neoplasms, and drugs must be excluded. | ||
* | *Uncommon. | ||
Serology: | |||
*Angiotensin-converting enzyme (ACE) - used for diagnosis and to monitor activity.<ref name=pmid24047001>{{Cite journal | last1 = Kaura | first1 = V. | last2 = Kaura | first2 = NV. | last3 = Kaura | first3 = BN. | last4 = Kaura | first4 = CS. | title = Angiotensin-converting enzyme inhibitors in the treatment of sarcoidosis and association with ACE gene polymorphism: case series. | journal = Indian J Chest Dis Allied Sci | volume = 55 | issue = 2 | pages = 105-7 | month = | year = | doi = | PMID = 24047001 }}</ref><ref name=pmid23897103>{{Cite journal | last1 = Stouten | first1 = K. | last2 = Werken | first2 = MV. | last3 = Tchetverikov | first3 = I. | last4 = Saboerali | first4 = M. | last5 = Vermeer | first5 = HJ. | last6 = Castel | first6 = R. | last7 = Verheijen | first7 = FM. | title = Extreme elevation of serum angiotensin-converting enzyme (ACE) activity: always consider familial ACE hyperactivity. | journal = Ann Clin Biochem | volume = | issue = | pages = | month = Jul | year = 2013 | doi = 10.1177/0004563213489812 | PMID = 23897103 }}</ref> | |||
**Elevated in approximately 65% of patients in one series.<ref name=pmid9327039>{{Cite journal | last1 = Shorr | first1 = AF. | last2 = Torrington | first2 = KG. | last3 = Parker | first3 = JM. | title = Serum angiotensin converting enzyme does not correlate with radiographic stage at initial diagnosis of sarcoidosis. | journal = Respir Med | volume = 91 | issue = 7 | pages = 399-401 | month = Aug | year = 1997 | doi = | PMID = 9327039 }}</ref> | |||
==Gross== | ==Gross== | ||
*Lungs - classic location.<ref name=pmid23597964>{{Cite journal | last1 = Rao | first1 = DA. | last2 = Dellaripa | first2 = PF. | title = Extrapulmonary manifestations of sarcoidosis. | journal = Rheum Dis Clin North Am | volume = 39 | issue = 2 | pages = 277-97 | month = May | year = 2013 | doi = 10.1016/j.rdc.2013.02.007 | PMID = 23597964 }} | *Lungs - classic location.<ref name=pmid23597964>{{Cite journal | last1 = Rao | first1 = DA. | last2 = Dellaripa | first2 = PF. | title = Extrapulmonary manifestations of sarcoidosis. | journal = Rheum Dis Clin North Am | volume = 39 | issue = 2 | pages = 277-97 | month = May | year = 2013 | doi = 10.1016/j.rdc.2013.02.007 | PMID = 23597964 }} | ||