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Difference between revisions of "Rhabdomyosarcoma"
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→IHC
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*Myogenin. | *Myogenin. | ||
For [[head and neck pathology|head and neck]] RMS:<ref name=pmid18487991>{{Cite journal | last1 = Bahrami | first1 = A. | last2 = Gown | first2 = AM. | last3 = Baird | first3 = GS. | last4 = Hicks | first4 = MJ. | last5 = Folpe | first5 = AL. | title = Aberrant expression of epithelial and neuroendocrine markers in alveolar rhabdomyosarcoma: a potentially serious diagnostic pitfall. | journal = Mod Pathol | volume = 21 | issue = 7 | pages = 795-806 | month = Jul | year = 2008 | doi = 10.1038/modpathol.2008.86 | PMID = 18487991 }}</ref> | |||
*CD56 +ve. | *CD56 +ve. | ||
*Synaptophysin -ve/+ve (seen in 12 of 37 cases<ref name=pmid18487991/>). | *Synaptophysin -ve/+ve (seen in 12 of 37 cases<ref name=pmid18487991/>). | ||
| Line 167: | Line 167: | ||
*Wide-spectrum cytokeratin -ve/+ve. | *Wide-spectrum cytokeratin -ve/+ve. | ||
*CAM5.2 -ve/+ve. | *CAM5.2 -ve/+ve. | ||
For [[urinary bladder]] RMS in adults: | |||
*Myogenin +ve. | |||
*Desmin +ve. | |||
*Keratins -ve.<ref name=pmid21762516>{{Cite journal | last1 = Bing | first1 = Z. | last2 = Zhang | first2 = PJ. | title = Adult urinary bladder tumors with rhabdomyosarcomatous differentiation: clinical, pathological and immunohistochemical studies. | journal = Diagn Pathol | volume = 6 | issue = | pages = 66 | month = | year = 2011 | doi = 10.1186/1746-1596-6-66 | PMID = 21762516 }}</ref> | |||
**Keratin positive tumours are considered ''rhabdomyosarcomatous sarcomatoid carcinoma'' or ''sarcomatoid carcinoma with rhabdomyosarcomatous differentiation''. | |||
===Subtyping via IHC=== | ===Subtyping via IHC=== | ||