Difference between revisions of "Rhabdomyoma"

From Libre Pathology
Jump to navigation Jump to search
 
(3 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Rhabdomyoma -- high mag.jpg
| Width      =
| Caption    = Rhabdomyoma. [[H&E stain]]. (WC)
| Synonyms  =
| Micro      = spider cells (large polygonal cells (~10-20x RBC diameter), abundant cytoplasm with clearing)
| Subtypes  = fetal rhabdomyoma, adult rhabdomyoma
| LMDDx      = [[granular cell tumour]], [[hibernoma]], [[oncocytoma]]
| Stains    =
| IHC        = desmin +ve, actin +ve, myoglobin +ve, S-100 -ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Staging    =
| Site      = [[heart]] (see ''[[cardiac tumours]]), [[head and neck pathology|head and neck]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Rhabdomyoma''' a benign muscle tumour.  Often seen in the context of [[tuberous sclerosis]].
'''Rhabdomyoma''' a benign muscle tumour.  Often seen in the context of [[tuberous sclerosis]].


Line 22: Line 54:


DDx:
DDx:
*[[Hibernoma]].
*[[Granular cell tumour]].
*[[Oncocytoma]].
*[[Lipoma]].
*[[Lipoma]].
*[[Fat necrosis]].
*[[Fat necrosis]].
*[[Hibernoma]].
*[[Granular cell tumour]].


===Images===
===Images===
Line 49: Line 82:
*Vimentin -ve/+ve.
*Vimentin -ve/+ve.
*S-100 -ve.
*S-100 -ve.
**Positive in granular cell tumour and hiberoma.
**Positive in granular cell tumour and hibernoma.


==See also==
==See also==
*[[Cardiac tumours]].
*[[Cardiac tumours]].
*[[Head and neck pathology]].


==References==
==References==

Latest revision as of 15:47, 22 April 2024

Rhabdomyoma
Diagnosis in short

Rhabdomyoma. H&E stain. (WC)

LM spider cells (large polygonal cells (~10-20x RBC diameter), abundant cytoplasm with clearing)
Subtypes fetal rhabdomyoma, adult rhabdomyoma
LM DDx granular cell tumour, hibernoma, oncocytoma
IHC desmin +ve, actin +ve, myoglobin +ve, S-100 -ve
Site heart (see cardiac tumours), head and neck

Prevalence rare
Prognosis benign

Rhabdomyoma a benign muscle tumour. Often seen in the context of tuberous sclerosis.

General

Gross

  • Solid, white/tan colour.

Image:

Microscopic

Features - cardiac:[3]

  • Spider cells:
    • Large polygonal cells (~10-20x RBC diameter):
      • Abundant cytoplasm filled with glycogen.

Note:

DDx:

Images

www

IHC

Features:[1]

  • Desmin +ve (21 of 21 adult cases[4]).
  • Myogoblin +ve.
  • Actin +ve (21 of 21 adult cases[4]).
  • Vimentin -ve/+ve.
  • S-100 -ve.
    • Positive in granular cell tumour and hibernoma.

See also

References

  1. 1.0 1.1 1.2 Hansen, T.; Katenkamp, D. (Nov 2005). "Rhabdomyoma of the head and neck: morphology and differential diagnosis.". Virchows Arch 447 (5): 849-54. doi:10.1007/s00428-005-0038-8. PMID 16133368.
  2. Neri, M.; Di Donato, S.; Maglietta, R.; Pomara, C.; Riezzo, I.; Turillazzi, E.; Fineschi, V. (Dec 2012). "Sudden death as presenting symptom caused by cardiac primary multicentric left ventricle rhabdomyoma, in an 11-month-old baby. An immunohistochemical study.". Diagn Pathol 7: 169. doi:10.1186/1746-1596-7-169. PMID 23206573.
  3. URL: http://www.brown.edu/Courses/Digital_Path/systemic_path/cardio/rhabdomyoma.html. Accessed on: 19 October 2011.
  4. 4.0 4.1 Kapadia, SB.; Meis, JM.; Frisman, DM.; Ellis, GL.; Heffner, DK.; Hyams, VJ. (Jun 1993). "Adult rhabdomyoma of the head and neck: a clinicopathologic and immunophenotypic study.". Hum Pathol 24 (6): 608-17. PMID 8505039.