Difference between revisions of "Rhabdomyoma"
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==IHC== | ==IHC== | ||
Features:<ref name=pmid16133368 >{{Cite journal | last1 = Hansen | first1 = T. | last2 = Katenkamp | first2 = D. | title = Rhabdomyoma of the head and neck: morphology and differential diagnosis. | journal = Virchows Arch | volume = 447 | issue = 5 | pages = 849-54 | month = Nov | year = 2005 | doi = 10.1007/s00428-005-0038-8 | PMID = 16133368 }}</ref> | Features:<ref name=pmid16133368 >{{Cite journal | last1 = Hansen | first1 = T. | last2 = Katenkamp | first2 = D. | title = Rhabdomyoma of the head and neck: morphology and differential diagnosis. | journal = Virchows Arch | volume = 447 | issue = 5 | pages = 849-54 | month = Nov | year = 2005 | doi = 10.1007/s00428-005-0038-8 | PMID = 16133368 }}</ref> | ||
*Desmin +ve. | *Desmin +ve (21 of 21 adult cases<ref name=pmid8505039>{{Cite journal | last1 = Kapadia | first1 = SB. | last2 = Meis | first2 = JM. | last3 = Frisman | first3 = DM. | last4 = Ellis | first4 = GL. | last5 = Heffner | first5 = DK. | last6 = Hyams | first6 = VJ. | title = Adult rhabdomyoma of the head and neck: a clinicopathologic and immunophenotypic study. | journal = Hum Pathol | volume = 24 | issue = 6 | pages = 608-17 | month = Jun | year = 1993 | doi = | PMID = 8505039 }}</ref>). | ||
*Myogoblin +ve. | *Myogoblin +ve. | ||
*Actin +ve. | *Actin +ve (21 of 21 adult cases<ref name=pmid8505039/>). | ||
*Vimentin -ve/+ve. | |||
*S-100 -ve. | *S-100 -ve. | ||
**Positive in granular cell tumour and hiberoma. | **Positive in granular cell tumour and hiberoma. | ||
Revision as of 14:39, 4 September 2017
Rhabdomyoma a benign muscle tumour. Often seen in the context of tuberous sclerosis.
General
- May be seen in the context of tuberous sclerosis.
- Rare benign mesenchymal tumour - may be seen in the head and neck.[1]
- Can cause death if in the heart.[2]
Gross
- Solid, white/tan colour.
Image:
Microscopic
Features - cardiac:[3]
- Spider cells:
- Large polygonal cells (~10-20x RBC diameter):
- Abundant cytoplasm filled with glycogen.
- Large polygonal cells (~10-20x RBC diameter):
Note:
- Fetal rhabdomyomas may have pseudoepitheliomatous hyperplasia.[1]
DDx:
Images
Rhabdomyoma - low mag. (WC)
Rhabdomyoma - intermed. mag. (WC)
Rhabdomyoma - high mag. (WC)
Rhabdomyoma - very high mag. (WC)
Rhabdomyoma - desmin - intermed. mag. (WC)
Rhabdomyoma - desmin - high mag. (WC)
www
IHC
Features:[1]
- Desmin +ve (21 of 21 adult cases[4]).
- Myogoblin +ve.
- Actin +ve (21 of 21 adult cases[4]).
- Vimentin -ve/+ve.
- S-100 -ve.
- Positive in granular cell tumour and hiberoma.
See also
References
- ↑ 1.0 1.1 1.2 Hansen, T.; Katenkamp, D. (Nov 2005). "Rhabdomyoma of the head and neck: morphology and differential diagnosis.". Virchows Arch 447 (5): 849-54. doi:10.1007/s00428-005-0038-8. PMID 16133368.
- ↑ Neri, M.; Di Donato, S.; Maglietta, R.; Pomara, C.; Riezzo, I.; Turillazzi, E.; Fineschi, V. (Dec 2012). "Sudden death as presenting symptom caused by cardiac primary multicentric left ventricle rhabdomyoma, in an 11-month-old baby. An immunohistochemical study.". Diagn Pathol 7: 169. doi:10.1186/1746-1596-7-169. PMID 23206573.
- ↑ URL: http://www.brown.edu/Courses/Digital_Path/systemic_path/cardio/rhabdomyoma.html. Accessed on: 19 October 2011.
- ↑ 4.0 4.1 Kapadia, SB.; Meis, JM.; Frisman, DM.; Ellis, GL.; Heffner, DK.; Hyams, VJ. (Jun 1993). "Adult rhabdomyoma of the head and neck: a clinicopathologic and immunophenotypic study.". Hum Pathol 24 (6): 608-17. PMID 8505039.