Difference between revisions of "Retinoblastoma"

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#redirect [[Eye#Retinoblastoma]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Rtbl400.GIF
| Width      =
| Caption    = Retinoblastoma. (WC)
| Synonyms  =
| Micro      = [[small round cell tumour]], Flexner-Wintersteiner [[rosette]]s, +/-Homer-Wright rosettes, mitoses (common), +/-necrosis, +/-calcifications
| Subtypes  =
| LMDDx      = retinocytoma, other [[small round cell tumours]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      = white, solid, friable
| Grossing  =
| Staging    =
| Site      = [[eye]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Retinoblastoma''' is a malignant tumour the of the [[eye]].
 
==General==
*Rare.
*[[Malignant]].
*May be familial.<ref name=pmid20687510>{{cite journal |author=Lohmann D |title=Retinoblastoma |journal=Adv. Exp. Med. Biol. |volume=685 |issue= |pages=220–7 |year=2010 |pmid=20687510 |doi= |url=}}</ref>
 
==Gross==
*White, solid.
*Patterns:
**Endophytic - grow into the  vitreous cavity.
**Exophytic - grow toward choroid.
**Mixed - components of endophytic and exophytic.
 
Note:
*Tumour is extremely friable.
 
===Image===
*[http://radiopaedia.org/cases/retinoblastoma-gross-pathology Retinoblastoma (radiopaedia.org/AFIP)].
 
==Microscopic==
Features:
*[[Small round cell tumour]]:
**Scant cytoplasm.
*Flexner-Wintersteiner [[rosette]] - '''key feature'''.
**Rosette with empty centre (donut hole).<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref>
*+/-Homer-Wright rosette.<ref>WH. 14 March 2011.</ref>
**Circular rosette with neuropil at the centre.<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref>
*Mitoses - common.
*+/-Necrosis.
*+/-Calcification.
 
DDx:
*Retinocytoma (retinoma) - benign counterpart of retinoblastoma.
 
Notes:
*DDx of Flexner-Wintersteiner rosette includes:
**Pineoblastoma.
**Medulloepithelioma.
 
===Images===
<gallery>
Image:Rtbl400.GIF | Retinoblastoma. (WC)
</gallery>
====www====
*[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/O0A001-PQ01-M.htm Retinoblastoma (ouhsc.edu)].
*[http://www.pathpedia.com/Education/eAtlas/Histopathology/eye_and_ocular_adnexa/retinoblastoma.aspx Retinoblastoma (pathpedia.com)].
 
==See also==
*[[Eye]].
*[[Small round cell tumours]].
 
==References==
{{Reflist|1}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Eye]]

Latest revision as of 03:55, 9 February 2016

Retinoblastoma
Diagnosis in short

Retinoblastoma. (WC)
LM small round cell tumour, Flexner-Wintersteiner rosettes, +/-Homer-Wright rosettes, mitoses (common), +/-necrosis, +/-calcifications
LM DDx retinocytoma, other small round cell tumours
Gross white, solid, friable
Site eye
Prevalence rare

Retinoblastoma is a malignant tumour the of the eye.

General

Gross

  • White, solid.
  • Patterns:
    • Endophytic - grow into the vitreous cavity.
    • Exophytic - grow toward choroid.
    • Mixed - components of endophytic and exophytic.

Note:

  • Tumour is extremely friable.

Image

Microscopic

Features:

  • Small round cell tumour:
    • Scant cytoplasm.
  • Flexner-Wintersteiner rosette - key feature.
    • Rosette with empty centre (donut hole).[2]
  • +/-Homer-Wright rosette.[3]
    • Circular rosette with neuropil at the centre.[2]
  • Mitoses - common.
  • +/-Necrosis.
  • +/-Calcification.

DDx:

  • Retinocytoma (retinoma) - benign counterpart of retinoblastoma.

Notes:

  • DDx of Flexner-Wintersteiner rosette includes:
    • Pineoblastoma.
    • Medulloepithelioma.

Images

  • Retinoblastoma. (WC)

www

See also

References

  1. ↑ Lohmann D (2010). "Retinoblastoma". Adv. Exp. Med. Biol. 685: 220–7. PMID 20687510.
  2. ↑ 2.0 2.1 Wippold FJ, Perry A (March 2006). "Neuropathology for the neuroradiologist: rosettes and pseudorosettes". AJNR Am J Neuroradiol 27 (3): 488–92. PMID 16551982.
  3. ↑ WH. 14 March 2011.
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