Renomedullary interstitial cell tumour

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Renomedullary interstitial cell tumour
Diagnosis in short

Renal medullary fibroma. H&E stain.

Synonyms renal medullary fibroma

LM small polygonal/stellate cells in abundant loose/myxoid stroma, +/-entrapped renal tubules
LM DDx renal myxoma, edge of medium-sized blood vessel
IHC alpha-SMA +ve, CD35 +ve
Gross small (usu. <3 mm), white, well-circumscribed nodule - medulla of kidney
Site kidney - see kidney tumours

Prevalence common
Prognosis benign

Renomedullary interstitial cell tumour, also known as medullary fibroma,[1] is a relatively common benign tumour of the kidney.


  • Benign.
  • Common autopsy finding[2] - one review says 26-41% of individuals at autopsy.[3]
    • The commonality is somewhat in dispute.[4]


  • Small, white well-circumscribed nodule in medulla.
    • Typically less than 3 mm.[3]




  • Small polygonal/stellate cells.
  • Abundant loose/myxoid stroma.
  • +/-Entrapped renal tubules.[6]


  • Renal myxoma.[7]
  • Edge of medium-sized blood vessel.





  • Alpha-smooth muscle actin +ve.
  • CD35 +ve.

See also


  1. Bircan, S.; Orhan, D.; Tulunay, O.; Safak, M. (2000). "Renomedullary interstitial cell tumor.". Urol Int 65 (3): 163-6. PMID 11054036.
  2. 2.0 2.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 295. ISBN 978-0781765275.
  3. 3.0 3.1 Tsurukawa, H.; Iuchi, H.; Osanai, H.; Yamaguchi, S.; Hashimoto, H.; Kaneko, S.; Yachiku, S. (Jan 2000). "[Renomedullary interstitial cell tumor: a case report].". Nihon Hinyokika Gakkai Zasshi 91 (1): 37-40. PMID 10689882.
  4. Kozłowska, J.; Okoń, K. (2008). "Renal tumors in postmortem material.". Pol J Pathol 59 (1): 21-5. PMID 18655367.
  5. URL: Accessed on: 17 October 2011.
  6. 6.0 6.1 Kuroda, N.; Toi, M.; Miyazaki, E.; Hayashi, Y.; Nakayama, H.; Hiroi, M.; Enzan, H.. "Participation of alpha-smooth muscle actin-positive cells in renomedullary interstitial cell tumors.". Oncol Rep 9 (4): 745-50. PMID 12066202.
  7. Melamed, J.; Reuter, VE.; Erlandson, RA.; Rosai, J. (Feb 1994). "Renal myxoma. A report of two cases and review of the literature.". Am J Surg Pathol 18 (2): 187-94. PMID 8291657.