Difference between revisions of "Renal angiomyoadenomatous tumour"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
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| Micro = leiomyomatous capsule of variable thickness, tubular structures with (1) apical snouts, and (2) clear cells with basal nuclei and mild [[nuclear atypia]] | |||
| Subtypes = | |||
| LMDDx = [[clear cell renal cell carcinoma]], [[papillary renal cell carcinoma]], (epithelioid) [[angiomyolipoma]], [[mixed epithelial and stromal tumour of the kidney|mixed epithelial and stromal tumour]] | |||
| Stains = | |||
| IHC = CK7 +ve, CK20 +ve, CAM5.2 +ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = tan-brown mass +/-cystic component | |||
| Grossing = | |||
| Site = [[kidney]] - see ''[[kidney tumours]]'' | |||
| Assdx = possibly related to [[clear cell papillary renal cell carcinoma]] | |||
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| Symptoms = | |||
| Prevalence = extremely very rare | |||
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| Prognosis = good | |||
| Other = | |||
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}} | |||
'''Renal angiomyoadenomatous tumour''', abbreviated '''RAT''', is an uncommon [[kidney tumour]] not recognized by the [[WHO]] classification of renal neoplasia or the Vancouver modification. | '''Renal angiomyoadenomatous tumour''', abbreviated '''RAT''', is an uncommon [[kidney tumour]] not recognized by the [[WHO]] classification of renal neoplasia or the Vancouver modification. | ||
Revision as of 05:07, 21 October 2014
| Renal angiomyoadenomatous tumour | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | leiomyomatous capsule of variable thickness, tubular structures with (1) apical snouts, and (2) clear cells with basal nuclei and mild nuclear atypia |
| LM DDx | clear cell renal cell carcinoma, papillary renal cell carcinoma, (epithelioid) angiomyolipoma, mixed epithelial and stromal tumour |
| IHC | CK7 +ve, CK20 +ve, CAM5.2 +ve |
| Gross | tan-brown mass +/-cystic component |
| Site | kidney - see kidney tumours |
|
| |
| Associated Dx | possibly related to clear cell papillary renal cell carcinoma |
| Prevalence | extremely very rare |
| Prognosis | good |
Renal angiomyoadenomatous tumour, abbreviated RAT, is an uncommon kidney tumour not recognized by the WHO classification of renal neoplasia or the Vancouver modification.
General
- May be on a spectrum with clear cell papillary renal cell carcinoma.[1]
Clincal:
- Typical age (years): 50s.[2]
- Age range: 40-93 years.
Gross
Features:[2]
- Tan-brown renal mass +/-cystic component.
Microscopic
- Leiomyomatous capsule of variable thickness - key feature.
- Tubular structures with:
- Apical snouts.
- Clear cells with basal nuclei and mild nuclear atypia.
- Clear cell renal cell carcinoma.
- Papillary renal cell carcinoma.
- Angiomyolipoma.
- Mixed epithelial and stromal tumour of the kidney.
IHC
Features:[3]
- CK7 +ve.
- CK20 +ve.
- CAM5.2 +ve.
- AE1/AE3 +ve.
See also
References
- ↑ Petersson, F.; Grossmann, P.; Hora, M.; Sperga, M.; Montiel, DP.; Martinek, P.; Gutierrez, ME.; Bulimbasic, S. et al. (Jul 2013). "Renal cell carcinoma with areas mimicking renal angiomyoadenomatous tumor/clear cell papillary renal cell carcinoma.". Hum Pathol 44 (7): 1412-20. doi:10.1016/j.humpath.2012.11.019. PMID 23434146.
- ↑ 2.0 2.1 2.2 2.3 Singh, C.; Kendi, AT.; Manivel, JC.; Pambuccian, SE. (Dec 2012). "Renal angiomyoadenomatous tumor.". Ann Diagn Pathol 16 (6): 470-6. doi:10.1016/j.anndiagpath.2012.01.006. PMID 22534244.
- ↑ 3.0 3.1 Michal, M.; Hes, O.; Nemcova, J.; Sima, R.; Kuroda, N.; Bulimbasic, S.; Franco, M.; Sakaida, N. et al. (Jan 2009). "Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity.". Virchows Arch 454 (1): 89-99. doi:10.1007/s00428-008-0697-3. PMID 19020896.
- ↑ Petersson, F.; Branzovsky, J.; Martinek, P.; Korabecna, M.; Kruslin, B.; Hora, M.; Peckova, K.; Bauleth, K. et al. (Jul 2014). "The leiomyomatous stroma in renal cell carcinomas is polyclonal and not part of the neoplastic process.". Virchows Arch 465 (1): 89-96. doi:10.1007/s00428-014-1591-9. PMID 24838683.