Difference between revisions of "Pyloric gland adenoma"

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| Caption    =  
| Caption    =  
| Synonyms  =
| Synonyms  =
| Micro      = round mildly irregular foveolar-type glands with round, basal, bland nuclei
| Micro      = foveolar-type glands with eosinophilic (or clear) cytoplasm, nuclei with or without dysplasia
| Subtypes  =
| Subtypes  =
| LMDDx      = foveolar-type [[gastric adenoma]], well-differentiated [[gastric adenocarcinoma]]
| LMDDx      = foveolar-type [[gastric adenoma]], well-differentiated [[gastric adenocarcinoma]]
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| Prognosis  = benign
| Prognosis  = benign
| Other      =
| Other      =
| ClinDDx    =
| ClinDDx    = other [[GI polyps|polyps]]
| Tx        =
| Tx        = excision
}}
}}
'''Pyloric gland adenoma''', abbreviated '''PGA''', is an uncommon [[gastrointestinal pathology|gastrointestinal]] lesion.
'''Pyloric gland adenoma''', abbreviated '''PGA''', is an uncommon [[gastrointestinal pathology|gastrointestinal]] lesion.
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==Microscopic==
==Microscopic==
Features:
Features:<ref name=pmid18830123/>
*Round mildly irregular foveolar-type glands with:  
*Round mildly irregular foveolar-type glands with:  
**Nuclei without dysplasia (round and basally located nuclei) or with dysplasia.
**Nuclei without dysplasia (round and basally located nuclei) or with dysplasia.
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*[[Gastric adenoma]], foveolar-type.
*[[Gastric adenoma]], foveolar-type.
*[[Adenocarcinoma of the stomach]], well-differentiated.
*[[Adenocarcinoma of the stomach]], well-differentiated.
===Images===
*[http://www.flickriver.com/photos/lunarcaustic/3488308419/ Tubulare adenoma, pyloric gland-type (flickriver.com)].


==IHC==
==IHC==
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**Negative in foveolar-type gastric adenomas.  
**Negative in foveolar-type gastric adenomas.  
*MUC5AC +ve.<ref name=pmid18830123/>
*MUC5AC +ve.<ref name=pmid18830123/>
==See also==
*[[Autoimmune gastritis]].


==References==
==References==
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[[Category:Gastrointestinal pathology]]
[[Category:Gastrointestinal pathology]]
[[Category:Diagnosis]]

Latest revision as of 17:53, 15 September 2022

Pyloric gland adenoma
Diagnosis in short

LM foveolar-type glands with eosinophilic (or clear) cytoplasm, nuclei with or without dysplasia
LM DDx foveolar-type gastric adenoma, well-differentiated gastric adenocarcinoma
IHC MUC6 +ve, MUC5AC +ve, Ki-67 high
Site stomach, duodenum, gallbladder, others

Associated Dx well-differentiated gastric adenocarcinoma, autoimmune gastritis
Prevalence uncommon
Endoscopy polyp
Prognosis benign
Clin. DDx other polyps
Treatment excision

Pyloric gland adenoma, abbreviated PGA, is an uncommon gastrointestinal lesion.

General

Microscopic

Features:[3]

  • Round mildly irregular foveolar-type glands with:
    • Nuclei without dysplasia (round and basally located nuclei) or with dysplasia.
    • Moderate eosinophilic (or clear) cytoplasm.

DDx:

Images

IHC

  • Ki-67 high.
  • MUC6 +ve.[3]
    • Negative in foveolar-type gastric adenomas.
  • MUC5AC +ve.[3]

See also

References

  1. Vieth, M.; Vogel, C.; Kushima, R.; Borchard, F.; Stolte, M. (Jan 2006). "Pyloric gland adenoma-- how to diagnose?". Cesk Patol 42 (1): 4-7. PMID 16506593.
  2. Vieth, M.; Montgomery, EA. (Aug 2014). "Some observations on pyloric gland adenoma: an uncommon and long ignored entity!". J Clin Pathol. doi:10.1136/jclinpath-2014-202553. PMID 25092673.
  3. 3.0 3.1 3.2 Chen, ZM.; Scudiere, JR.; Abraham, SC.; Montgomery, E. (Feb 2009). "Pyloric gland adenoma: an entity distinct from gastric foveolar type adenoma.". Am J Surg Pathol 33 (2): 186-93. doi:10.1097/PAS.0b013e31817d7ff4. PMID 18830123.