Difference between revisions of "Pulmonary neuroendocrine cell hyperplasia"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = | |||
| Width = | |||
| Caption = | |||
| Synonyms = | |||
| Micro = proliferation of neuroendocrine cells confined by the basement membrane of the bronchus. | |||
| Subtypes = | |||
| LMDDx = [[carcinoid tumourlet]], [[diffuse idiopathic pulmonary neuroendocrine cell hyperplasia]], [[pulmonary meningothelial-like nodule]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[lung]] | |||
| Assdx = | |||
| Syndromes = if diffuse ''[[diffuse idiopathic pulmonary neuroendocrine cell hyperplasia]] (DIPNECH)'' | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = none | |||
| Prevalence = very common | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = none required | |||
}} | |||
'''Pulmonary neuroendocrine cell hyperplasia''' is a proliferation of neuroendocrine cells confined by the bronchial basement membrane. | '''Pulmonary neuroendocrine cell hyperplasia''' is a proliferation of neuroendocrine cells confined by the bronchial basement membrane. | ||
==General== | ==General== | ||
*Common. | *Common. | ||
*May be seen in the context of [[diffuse idiopathic pulmonary neuroendocrine cell hyperplasia]]. | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
* | *Proliferation of neuroendocrine cells - superficial to the basement membrane of the bronchus.<ref name=pmid20729444>{{Cite journal | last1 = Koo | first1 = CW. | last2 = Baliff | first2 = JP. | last3 = Torigian | first3 = DA. | last4 = Litzky | first4 = LA. | last5 = Gefter | first5 = WB. | last6 = Akers | first6 = SR. | title = Spectrum of pulmonary neuroendocrine cell proliferation: diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, tumorlet, and carcinoids. | journal = AJR Am J Roentgenol | volume = 195 | issue = 3 | pages = 661-8 | month = Sep | year = 2010 | doi = 10.2214/AJR.09.3811 | PMID = 20729444 }}</ref><ref name=pmid17099078>{{Cite journal | last1 = Davies | first1 = SJ. | last2 = Gosney | first2 = JR. | last3 = Hansell | first3 = DM. | last4 = Wells | first4 = AU. | last5 = du Bois | first5 = RM. | last6 = Burke | first6 = MM. | last7 = Sheppard | first7 = MN. | last8 = Nicholson | first8 = AG. | title = Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under-recognised spectrum of disease. | journal = Thorax | volume = 62 | issue = 3 | pages = 248-52 | month = Mar | year = 2007 | doi = 10.1136/thx.2006.063065 | PMID = 17099078 }}</ref> | ||
**Salt and pepper chromatin. | **Salt and pepper chromatin. | ||
* | |||
Note: | |||
*They often project into the airway. | |||
DDx: | DDx: | ||
*[[Carcinoid tumourlet]] - extends beyond the basement membrane and less than 5 mm in maximal dimension. | *[[Carcinoid tumourlet]] - extends beyond the basement membrane and less than 5 mm in maximal dimension. | ||
*[[Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia]]. | |||
*[[Pulmonary meningothelial-like nodule]]. | |||
==See also== | ==See also== | ||
*[[Neuroendocrine tumours]]. | *[[Neuroendocrine tumours]]. | ||
*[[Neuroendocrine markers]]. | *[[Neuroendocrine markers]]. | ||
*[[Lung tumours]]. | |||
==References== | ==References== | ||
Latest revision as of 22:14, 16 December 2015
| Pulmonary neuroendocrine cell hyperplasia | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | proliferation of neuroendocrine cells confined by the basement membrane of the bronchus. |
| LM DDx | carcinoid tumourlet, diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, pulmonary meningothelial-like nodule |
| Site | lung |
|
| |
| Syndromes | if diffuse diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) |
|
| |
| Symptoms | none |
| Prevalence | very common |
| Prognosis | benign |
| Treatment | none required |
Pulmonary neuroendocrine cell hyperplasia is a proliferation of neuroendocrine cells confined by the bronchial basement membrane.
General
- Common.
- May be seen in the context of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia.
Microscopic
Features:
- Proliferation of neuroendocrine cells - superficial to the basement membrane of the bronchus.[1][2]
- Salt and pepper chromatin.
Note:
- They often project into the airway.
DDx:
- Carcinoid tumourlet - extends beyond the basement membrane and less than 5 mm in maximal dimension.
- Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia.
- Pulmonary meningothelial-like nodule.
See also
References
- ↑ Koo, CW.; Baliff, JP.; Torigian, DA.; Litzky, LA.; Gefter, WB.; Akers, SR. (Sep 2010). "Spectrum of pulmonary neuroendocrine cell proliferation: diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, tumorlet, and carcinoids.". AJR Am J Roentgenol 195 (3): 661-8. doi:10.2214/AJR.09.3811. PMID 20729444.
- ↑ Davies, SJ.; Gosney, JR.; Hansell, DM.; Wells, AU.; du Bois, RM.; Burke, MM.; Sheppard, MN.; Nicholson, AG. (Mar 2007). "Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under-recognised spectrum of disease.". Thorax 62 (3): 248-52. doi:10.1136/thx.2006.063065. PMID 17099078.