Proton pump inhibitor effect

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Proton pump inhibitor effect, abbreviated PPI effect, is a change seen in the parietal cells of the stomach due to a drug in the proton pump inhibitor class.

Stomach with PPI effect. H&E stain.

Formally, it is stomach with proton pump inhibitor effect.

General

Some proton pump inhibitors:

  • Omeprazole (LOSEC).
  • Dexlansoprazole (DEXILANT).
  • Lansoprazole (PREVACID).
  • Esomeprazole (NEXIUM).
  • Pantoprazole (PANTOLOC).
  • Rabeprazole (PARIET).

Microscopic

Features:[1]

  • Parietal cell enlargement - key feature.
    • Parietal cells typically bulge into the lumen.

Images

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  • Usually not reported.

See also

References

  1. Driman, DK.; Wright, C.; Tougas, G.; Riddell, RH. (Oct 1996). "Omeprazole produces parietal cell hypertrophy and hyperplasia in humans.". Dig Dis Sci 41 (10): 2039-47. PMID 8888719.