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Difference between revisions of "Proton pump inhibitor effect"
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==Microscopic== | ==Microscopic== | ||
Features:<ref>{{Cite journal | last1 = Driman | first1 = DK. | last2 = Wright | first2 = C. | last3 = Tougas | first3 = G. | last4 = Riddell | first4 = RH. | title = Omeprazole produces parietal cell hypertrophy and hyperplasia in humans. | journal = Dig Dis Sci | volume = 41 | issue = 10 | pages = 2039-47 | month = Oct | year = 1996 | doi = | PMID = 8888719 }}</ref> <ref>{{Pathologyoutlines| topic/stomachPPI}}</ref> | Features:<ref name=pmid8888719>{{Cite journal | last1 = Driman | first1 = DK. | last2 = Wright | first2 = C. | last3 = Tougas | first3 = G. | last4 = Riddell | first4 = RH. | title = Omeprazole produces parietal cell hypertrophy and hyperplasia in humans. | journal = Dig Dis Sci | volume = 41 | issue = 10 | pages = 2039-47 | month = Oct | year = 1996 | doi = | PMID = 8888719 }}</ref><ref>{{Pathologyoutlines| topic/stomachPPI}}</ref> | ||
*Parietal cell enlargement - '''key feature'''. | *Parietal cell enlargement - '''key feature'''. | ||
**Parietal cells typically bulge into the lumen. | **Parietal cells typically bulge into the lumen. | ||
*G cell and enterochromaffin cell-like hyperplasia | *G cell and enterochromaffin cell-like hyperplasia. | ||
**Compensatory change due to increased pH in gastric lumen. | **Compensatory change due to increased pH in gastric lumen. | ||
*Multiple fundic gland polyps (with PPI use over several months) | *Multiple fundic gland polyps (with PPI use over several months). | ||
**Polyps may regress after PPI is stopped | **Polyps may regress after PPI is stopped. | ||
===Images=== | ===Images=== | ||