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Difference between revisions of "Proton pump inhibitor effect"
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*Due to intake of a proton pump inhibitor (PPI). | *Due to intake of a proton pump inhibitor (PPI). | ||
**Used to treat [[gastroesophageal reflux disease]]. | **Used to treat [[gastroesophageal reflux disease]]. | ||
===Some proton pump inhibitors=== | |||
{| class="wikitable sortable" | |||
! Generic name | |||
! Brand name(s) | |||
|- | |||
|Omeprazole | |||
|LOSEC | |||
|- | |||
|Dexlansoprazole | |||
|DEXILANT | |||
|- | |||
|Lansoprazole | |||
|PREVACID | |||
|- | |||
|Esomeprazole | |||
|NEXIUM | |||
|- | |||
|Pantoprazole | |||
|PANTOLOC | |||
|- | |||
|Rabeprazole | |||
|PARIET | |||
|} | |||
==Microscopic== | ==Microscopic== | ||
Features:<ref>{{Cite journal | last1 = Driman | first1 = DK. | last2 = Wright | first2 = C. | last3 = Tougas | first3 = G. | last4 = Riddell | first4 = RH. | title = Omeprazole produces parietal cell hypertrophy and hyperplasia in humans. | journal = Dig Dis Sci | volume = 41 | issue = 10 | pages = 2039-47 | month = Oct | year = 1996 | doi = | PMID = 8888719 }}</ref> | Features:<ref name=pmid8888719>{{Cite journal | last1 = Driman | first1 = DK. | last2 = Wright | first2 = C. | last3 = Tougas | first3 = G. | last4 = Riddell | first4 = RH. | title = Omeprazole produces parietal cell hypertrophy and hyperplasia in humans. | journal = Dig Dis Sci | volume = 41 | issue = 10 | pages = 2039-47 | month = Oct | year = 1996 | doi = | PMID = 8888719 }}</ref><ref>{{Pathologyoutlines| topic/stomachPPI}}</ref> | ||
*Parietal cell enlargement - '''key feature'''. | *Parietal cell enlargement - '''key feature'''. | ||
**Parietal cells typically bulge into the lumen. | **Parietal cells typically bulge into the lumen. | ||
*G cell and enterochromaffin cell-like hyperplasia. | |||
**Compensatory change due to increased pH in gastric lumen. | |||
*Multiple fundic gland polyps (with PPI use over several months). | |||
**Polyps may regress after PPI is stopped. | |||
===Images=== | ===Images=== | ||
| Line 27: | Line 55: | ||
==See also== | ==See also== | ||
*[[Stomach]]. | *[[Stomach]]. | ||
*[[Glycogenic acanthosis of the esophagus]]. | |||
==References== | ==References== | ||