48,453
edits
Difference between revisions of "Progressive transformation of germinal centers"
Jump to navigation
Jump to search
Progressive transformation of germinal centers (view source)
Revision as of 04:22, 5 September 2013
, 04:22, 5 September 2013→Microscopic: +images
(+additional refs) |
(→Microscopic: +images) |
||
| (3 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Progressive_transformation_of_germinal_centres_-1-_very_low_mag.jpg | |||
| Width = | |||
| Caption = PTGC. [[H&E stain]]. | |||
| Micro = follicular hyperplasia with focally large germinal centers with a poorly demarcated germinal center (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes), expanded mantle zone | |||
| Subtypes = | |||
| LMDDx = [[nodular lymphocyte predominant Hodgkin lymphoma]], other lymphomas | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[lymph node]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = lymphadenopathy | |||
| Symptoms = asymptomatic | |||
| Prevalence = very rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = [[lymph node metastasis]], [[lymphoma]] | |||
}} | |||
'''Progressive transformation of germinal centers''', abbreviated '''PTGC''', is a rare [[lymph node pathology]]. | '''Progressive transformation of germinal centers''', abbreviated '''PTGC''', is a rare [[lymph node pathology]]. | ||
| Line 4: | Line 33: | ||
*Benign. | *Benign. | ||
*Classically in younger patients. | *Classically in younger patients. | ||
*Associated with nodular lymphocyte predominant | *Associated with [[nodular lymphocyte predominant Hodgkin lymphoma]] (NLPHL); NLPHL found in up to 5% in a 7 year follow-up.<ref name=pmid12145465>{{cite journal |author=Verma A, Stock W, Norohna S, Shah R, Bradlow B, Platanias LC |title=Progressive transformation of germinal centers. Report of 2 cases and review of the literature |journal=Acta Haematol. |volume=108 |issue=1 |pages=33–8 |year=2002 |pmid=12145465 |doi= |url=}}</ref> | ||
Clinical: | Clinical: | ||
| Line 16: | Line 45: | ||
**Expanded mantle zone. | **Expanded mantle zone. | ||
Images: | ===Images=== | ||
<gallery> | |||
Image:Progressive transformation of germinal centres -1- low mag.jpg| PTGCs - low mag. (WC) | |||
Image:Progressive transformation of germinal centres -1- intermed mag.jpg| PTGCs - intermed. mag. (WC) | |||
</gallery> | |||
<gallery> | |||
Image:Progressive transformation of germinal centers -2- very low mag.jpg| PTGCs - very low mag. (WC) | |||
Image:Progressive transformation of germinal centers -2- low mag.jpg| PTGCs - low mag. (WC) | |||
Image:Progressive transformation of germinal centers -2- intermed mag.jpg| PTGCs - intermed. mag. (WC) | |||
</gallery> | |||
==See also== | ==See also== | ||
| Line 33: | Line 69: | ||
[[Category:Lymph node pathology]] | [[Category:Lymph node pathology]] | ||
[[Category:Diagnosis]] | |||