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Progressive transformation of germinal centers (view source)
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'''Progressive transformation of germinal centers''', abbreviated '''PTGC''', is a rare | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Progressive_transformation_of_germinal_centres_-1-_very_low_mag.jpg | |||
| Width = | |||
| Caption = PTGC. [[H&E stain]]. | |||
| Micro = follicular hyperplasia with focally large germinal centers with a poorly demarcated germinal center (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes), expanded mantle zone | |||
| Subtypes = | |||
| LMDDx = [[nodular lymphocyte predominant Hodgkin lymphoma]], other lymphomas | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[lymph node]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = lymphadenopathy | |||
| Symptoms = asymptomatic | |||
| Prevalence = very rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = [[lymph node metastasis]], [[lymphoma]] | |||
}} | |||
'''Progressive transformation of germinal centers''', abbreviated '''PTGC''', is a rare [[lymph node pathology]]. | |||
==General== | ==General== | ||
*Benign. | *Benign. | ||
*Classically in younger patients. | *Classically in younger patients. | ||
*Associated with nodular lymphocyte predominant | *Associated with [[nodular lymphocyte predominant Hodgkin lymphoma]] (NLPHL); NLPHL found in up to 5% in a 7 year follow-up.<ref name=pmid12145465>{{cite journal |author=Verma A, Stock W, Norohna S, Shah R, Bradlow B, Platanias LC |title=Progressive transformation of germinal centers. Report of 2 cases and review of the literature |journal=Acta Haematol. |volume=108 |issue=1 |pages=33–8 |year=2002 |pmid=12145465 |doi= |url=}}</ref> | ||
Clinical: | Clinical: | ||
| Line 16: | Line 45: | ||
**Expanded mantle zone. | **Expanded mantle zone. | ||
Images: | ===Images=== | ||
<gallery> | |||
Image:Progressive transformation of germinal centres -1- low mag.jpg| PTGCs - low mag. (WC) | |||
Image:Progressive transformation of germinal centres -1- intermed mag.jpg| PTGCs - intermed. mag. (WC) | |||
</gallery> | |||
<gallery> | |||
Image:Progressive transformation of germinal centers -2- very low mag.jpg| PTGCs - very low mag. (WC) | |||
Image:Progressive transformation of germinal centers -2- low mag.jpg| PTGCs - low mag. (WC) | |||
Image:Progressive transformation of germinal centers -2- intermed mag.jpg| PTGCs - intermed. mag. (WC) | |||
</gallery> | |||
==See also== | ==See also== | ||
*[[Lymph node pathology]]. | *[[Lymph node pathology]]. | ||
*[[Lymph node]]. | |||
*[[Haematopathology]]. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|1}} | ||
==Additional reading== | |||
*{{cite journal |author=Hansmann ML, Fellbaum C, Hui PK, Moubayed P |title=Progressive transformation of germinal centers with and without association to Hodgkin's disease |journal=Am. J. Clin. Pathol. |volume=93 |issue=2 |pages=219–26 |year=1990 |month=February |pmid=2405631 |doi= |url=}} | |||
*{{cite journal |author=Kojima M, Nakamura S, Motoori T, ''et al.'' |title=Progressive transformation of germinal centers: a clinicopathological study of 42 Japanese patients |journal=Int. J. Surg. Pathol. |volume=11 |issue=2 |pages=101–7 |year=2003 |month=April |pmid=12754626 |doi= |url=}} | |||
[[Category:Lymph node pathology]] | [[Category:Lymph node pathology]] | ||
[[Category:Diagnosis]] | |||