Difference between revisions of "Postradiation prostatic carcinoma"
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*Nuclear enlargement and nucleoli are prevalent in [[radiation changes]] of the prostate. These features are not useful in this context.<ref name=pmid10524518/> | *Nuclear enlargement and prominent [[nucleoli]] are prevalent in [[radiation changes]] of the prostate. These features are not useful in this context.<ref name=pmid10524518/> | ||
DDx: | DDx: | ||
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*Postradiation prostatic sarcoma.<ref name=pmid11763492>{{Cite journal | last1 = Canfield | first1 = SE. | last2 = Gans | first2 = TH. | last3 = Unger | first3 = P. | last4 = Hall | first4 = SJ. | title = Postradiation prostatic sarcoma: de novo carcinogenesis or dedifferentiation of prostatic adenocarcinoma? | journal = Tech Urol | volume = 7 | issue = 4 | pages = 294-5 | month = Dec | year = 2001 | doi = | PMID = 11763492 }}</ref> | *Postradiation prostatic sarcoma.<ref name=pmid11763492>{{Cite journal | last1 = Canfield | first1 = SE. | last2 = Gans | first2 = TH. | last3 = Unger | first3 = P. | last4 = Hall | first4 = SJ. | title = Postradiation prostatic sarcoma: de novo carcinogenesis or dedifferentiation of prostatic adenocarcinoma? | journal = Tech Urol | volume = 7 | issue = 4 | pages = 294-5 | month = Dec | year = 2001 | doi = | PMID = 11763492 }}</ref> | ||
*[[Sarcomatoid prostatic carcinoma]] - may arise following radiation. | *[[Sarcomatoid prostatic carcinoma]] - may arise following radiation. | ||
===Images=== | |||
<gallery> | |||
Image: Prostatic carcinoma and radiation changes -- intermed mag.jpg | PC and RC - intermed. mag. | |||
Image: Prostatic carcinoma and radiation changes - alt -- intermed mag.jpg | PC and RC - intermed. mag. | |||
Image: Prostatic carcinoma and radiation changes -- high mag.jpg | PC and RC - high mag. | |||
Image: Prostatic carcinoma and radiation changes -- very high mag.jpg | PC and RC - very high mag. | |||
Image: Radiation changes in the prostate - alt -- high mag.jpg | RC - high mag. | |||
Image: Radiation changes in the prostate - alt -- very high mag.jpg | RC - very high mag. | |||
</gallery> | |||
==IHC== | ==IHC== | ||
Revision as of 05:04, 23 July 2015
Postradiation prostatic carcinoma, also prostate carcinoma after radiation therapy, is uncommon but may be challenging to diagnose.[1]
General
- Overcall and undercall are both seen.[1]
- Commonly missed on core biopsies.
- History of radiation.
Microscopic
Features:[1]
- Infiltrative growth (diagnostic).
- Perineural invasion (diagnostic).
- Intraluminal crystalloids.
- Blue mucin secretions.
- Absence of corpora amylacea.
- Coexistent high-grade prostatic intraepithelial neoplasia.
Note:
- Nuclear enlargement and prominent nucleoli are prevalent in radiation changes of the prostate. These features are not useful in this context.[1]
DDx:
- Radiation changes.
- Pleomorphic tumours.
- Postradiation prostatic sarcoma.[2]
- Sarcomatoid prostatic carcinoma - may arise following radiation.
Images
PC and RC - intermed. mag.
PC and RC - intermed. mag.
PC and RC - high mag.
PC and RC - very high mag.
RC - high mag.
RC - very high mag.
IHC
- AMACR +ve.
- CK5/6 -ve.
- p63 -ve.
See also
References
- ↑ 1.0 1.1 1.2 1.3 Cheng, L.; Cheville, JC.; Bostwick, DG. (Oct 1999). "Diagnosis of prostate cancer in needle biopsies after radiation therapy.". Am J Surg Pathol 23 (10): 1173-83. PMID 10524518.
- ↑ Canfield, SE.; Gans, TH.; Unger, P.; Hall, SJ. (Dec 2001). "Postradiation prostatic sarcoma: de novo carcinogenesis or dedifferentiation of prostatic adenocarcinoma?". Tech Urol 7 (4): 294-5. PMID 11763492.