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Difference between revisions of "Porocarcinoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Porocarcinoma - alt -- low mag.jpg | |||
| Width = | |||
| Caption = Porocarcinoma. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = | |||
| Subtypes = | |||
| LMDDx = [[basal cell carcinoma]], [[squamous cell carcinoma of the skin|squamous cell carcinoma]], [[pyogenic granuloma]], [[verruca vulgaris]], | |||
[[adenocarcinoma]], [[malignant melanoma]] | |||
| Stains = | |||
| IHC = [[CD117]] +ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = skin - typically head & neck | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = very rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = poor | |||
| Other = | |||
| ClinDDx = | |||
| Tx = surgical excision | |||
}} | |||
'''Porocarcinoma''' is a rare [[malignant]] [[skin tumour]] that has an aggressive behaviour.<ref name=pmid28721214>{{Cite journal | last1 = Salih | first1 = AM. | last2 = Kakamad | first2 = FH. | last3 = Baba | first3 = HO. | last4 = Salih | first4 = RQ. | last5 = Hawbash | first5 = MR. | last6 = Mohammed | first6 = SH. | last7 = Othman | first7 = S. | last8 = Saeed | first8 = YA. | last9 = Habibullah | first9 = IJ. | title = Porocarcinoma; presentation and management, a meta-analysis of 453 cases. | journal = Ann Med Surg (Lond) | volume = 20 | issue = | pages = 74-79 | month = Aug | year = 2017 | doi = 10.1016/j.amsu.2017.06.027 | PMID = 28721214 }}</ref> | '''Porocarcinoma''' is a rare [[malignant]] [[skin tumour]] that has an aggressive behaviour.<ref name=pmid28721214>{{Cite journal | last1 = Salih | first1 = AM. | last2 = Kakamad | first2 = FH. | last3 = Baba | first3 = HO. | last4 = Salih | first4 = RQ. | last5 = Hawbash | first5 = MR. | last6 = Mohammed | first6 = SH. | last7 = Othman | first7 = S. | last8 = Saeed | first8 = YA. | last9 = Habibullah | first9 = IJ. | title = Porocarcinoma; presentation and management, a meta-analysis of 453 cases. | journal = Ann Med Surg (Lond) | volume = 20 | issue = | pages = 74-79 | month = Aug | year = 2017 | doi = 10.1016/j.amsu.2017.06.027 | PMID = 28721214 }}</ref> | ||
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*Very rare ~ most papers are case reports.<ref name=pmid25515648>{{Cite journal | last1 = Riera-Leal | first1 = L. | last2 = Guevara-Gutiérrez | first2 = E. | last3 = Barrientos-García | first3 = JG. | last4 = Madrigal-Kasem | first4 = R. | last5 = Briseño-Rodríguez | first5 = G. | last6 = Tlacuilo-Parra | first6 = A. | title = Eccrine porocarcinoma: epidemiologic and histopathologic characteristics. | journal = Int J Dermatol | volume = 54 | issue = 5 | pages = 580-6 | month = | year = 2015 | doi = 10.1111/ijd.12714 | PMID = 25515648 }}</ref> | *Very rare ~ most papers are case reports.<ref name=pmid25515648>{{Cite journal | last1 = Riera-Leal | first1 = L. | last2 = Guevara-Gutiérrez | first2 = E. | last3 = Barrientos-García | first3 = JG. | last4 = Madrigal-Kasem | first4 = R. | last5 = Briseño-Rodríguez | first5 = G. | last6 = Tlacuilo-Parra | first6 = A. | title = Eccrine porocarcinoma: epidemiologic and histopathologic characteristics. | journal = Int J Dermatol | volume = 54 | issue = 5 | pages = 580-6 | month = | year = 2015 | doi = 10.1111/ijd.12714 | PMID = 25515648 }}</ref> | ||
Clinical - based on meta-analysis of 453 cases: | Clinical features - based on meta-analysis of 453 cases:<ref name=pmid28721214/> | ||
*No predominance males versus females. | *No predominance males versus females. | ||
*Aggressive behaviour >30% of cases have metastases at presentation - typically to lymph nodes. | *Aggressive behaviour >30% of cases have metastases at presentation - typically to lymph nodes. | ||
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===Images=== | ===Images=== | ||
<gallery> | |||
Image: Porocarcinoma -- very low mag.jpg | Porocarcinoma - very low mag. | |||
Image: Porocarcinoma -- low mag.jpg | Porocarcinoma - low mag. | |||
Image: Porocarcinoma -- intermed mag.jpg | Porocarcinoma - intermed. mag. | |||
Image: Porocarcinoma - alt -- intermed mag.jpg | Porocarcinoma - intermed. mag. | |||
Image: Porocarcinoma -- high mag.jpg | Porocarcinoma - high mag. | |||
Image: Porocarcinoma -- very high mag.jpg | Porocarcinoma - very high mag. | |||
</gallery> | |||
====www==== | |||
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595608/figure/f4/?report=objectonly Eccrine porocarcinoma (nih.gov)].<ref name=pmid28954110/> | *[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595608/figure/f4/?report=objectonly Eccrine porocarcinoma (nih.gov)].<ref name=pmid28954110/> | ||
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884174/figure/F2/ Porocarcinoma (nih.gov)].<ref name=pmid24403888>{{Cite journal | last1 = Kurashige | first1 = Y. | last2 = Minemura | first2 = T. | last3 = Nagatani | first3 = T. | title = Eccrine porocarcinoma: clinical and pathological report of eight cases. | journal = Case Rep Dermatol | volume = 5 | issue = 3 | pages = 259-66 | month = | year = 2013 | doi = 10.1159/000355606 | PMID = 24403888 }}</ref> | |||
==IHC== | |||
Features:<ref>{{Cite journal | last1 = Goto | first1 = K. | last2 = Takai | first2 = T. | last3 = Fukumoto | first3 = T. | last4 = Anan | first4 = T. | last5 = Kimura | first5 = T. | last6 = Ansai | first6 = S. | last7 = Oshitani | first7 = Y. | last8 = Murata | first8 = Y. | last9 = Sakuma | first9 = T. | title = CD117 (KIT) is a useful immunohistochemical marker for differentiating porocarcinoma from squamous cell carcinoma. | journal = J Cutan Pathol | volume = 43 | issue = 3 | pages = 219-26 | month = Mar | year = 2016 | doi = 10.1111/cup.12632 | PMID = 26449497 }}</ref> | |||
*[[CD117]] +ve (~100% of porocarcinoma, ~20% of [[squamous carcinoma]]s focally). | |||
==See also== | ==See also== | ||
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[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Dermatopathology]] | |||