Difference between revisions of "Poorly differentiated carcinoma of the lung"
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'''Poorly differentiated carcinoma of the lung''', also '''poorly differentiated lung carcinoma''', is an unclassified [[lung tumour]] with features of [[small cell carcinoma of the lung|small cell carcinoma]] and [[non-small cell carcinoma]]. | '''Poorly differentiated carcinoma of the lung''', also '''poorly differentiated lung carcinoma''', is an unclassified [[lung tumour]] with features of [[small cell carcinoma of the lung|small cell carcinoma]] and [[non-small cell lung carcinoma]]. | ||
Categorically, it is | Categorically, it is grouped with [[non-small cell lung cancer]]. | ||
==General== | ==General== | ||
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The tumour stains as follows: | The tumour stains as follows: | ||
POSITIVE: EMA, AE1/AE3. | POSITIVE: EMA, AE1/AE3. | ||
NEGATIVE: TTF-1, chromogranin A, synaptophysin, CD56, CD45. | NEGATIVE: TTF-1, chromogranin A, synaptophysin, CD56, CD45, CK5/6, p63. | ||
The morphology would be compatible with small cell carcinoma or basaloid | The morphology would be compatible with small cell carcinoma or basaloid | ||
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==See also== | ==See also== | ||
*[[Lung tumours]]. | *[[Lung tumours]]. | ||
*[[Non-small cell lung carcinoma]]. | |||
[[Category:Lung tumours]] | [[Category:Lung tumours]] | ||
Revision as of 03:51, 18 November 2015
Poorly differentiated carcinoma of the lung, also poorly differentiated lung carcinoma, is an unclassified lung tumour with features of small cell carcinoma and non-small cell lung carcinoma.
Categorically, it is grouped with non-small cell lung cancer.
General
- Should be used when the DDx is small cell carcinoma versus non-small cell carcinoma.
- Poorly differentiated carcinoma leaves the surgical options on the table.
Microscopic
Features:
- Small cell carcinoma/basaloid squamous cell carcinoma-like tumour.
DDx:
IHC
- Lack of staining with neuroendocrine markers (chromogranin A -ve, synaptophysin -ve, CD56 -ve).
- Keratins +ve.
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Lung, Left Lower Lobe, Core Biopsy: - POORLY DIFFERENTIATED CARCINOMA, see comment. COMMENT: The tumour stains as follows: POSITIVE: EMA, AE1/AE3. NEGATIVE: TTF-1, chromogranin A, synaptophysin, CD56, CD45, CK5/6, p63. The morphology would be compatible with small cell carcinoma or basaloid squamous cell carcinoma. The neuroendocrine markers (chromogranin A, synaptophysin, CD56) and the squamoid markers available (p63, CK5/6) are negative; thus, the tumour is not further classified.