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Plasma cell neoplasms (view source)
Revision as of 17:22, 12 December 2016
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Plasma cell neoplasm -- very high mag.jpg | |||
| Width = | |||
| Caption = Plasma cell neoplasm. [[H&E stain]] | |||
| Synonyms = | |||
| Micro = dyscohesive plasmacytoid cells (abundant cytoplasm, eccentrically placed nucleus), often prominent perinuclear hof, +/-nucleoli, +/-Russell bodies, +/-Dutcher bodies | |||
| Subtypes = | |||
| LMDDx = [[lymphoplasmacytic lymphoma]], [[neuroendocrine carcinoma]], poorly differentiated carcinoma, others | |||
| Stains = | |||
| IHC = [[CD138]] +ve, CD56 +ve, CD45 -ve/+ve, CD79a +ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[bone]] - [[bone marrow]] | |||
| Assdx = [[renal failure]], [[myeloma cast nephropathy]] | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = | |||
| Bloodwork = +/-[[anemia]], +/-hypercalcemia | |||
| Rads = +/-lytic bone lesions | |||
| Endoscopy = | |||
| Prognosis = poor | |||
| Other = | |||
| ClinDDx = [[metastatic disease]] | |||
| Tx = | |||
}} | |||
'''Plasma cell neoplasms''' arise from [[plasma cell]]s. They are encountered by anatomical pathologists on occasion. | '''Plasma cell neoplasms''' arise from [[plasma cell]]s. They are encountered by anatomical pathologists on occasion. | ||
''Plasma cell myeloma'', and ''plasmacytoma'' (solitary myeloma)<ref name=Ref_PCPBoD8_324>{{Ref PCPBoD8|324}}</ref> redirect to this article. | |||
==General== | ==General== | ||
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===Images=== | ===Images=== | ||
=====Case===== | |||
<gallery> | |||
Image: Plasma cell neoplasm -- low mag.jpg | PCN - low mag. | |||
Image: Plasma cell neoplasm -- intermed mag.jpg | PCN - intermed. mag. | |||
Image: Plasma cell neoplasm -- high mag.jpg | PCN - high mag. | |||
Image: Plasma cell neoplasm -- very high mag.jpg | PCN - very high mag. | |||
</gallery> | |||
=====Other cases===== | |||
<gallery> | <gallery> | ||
Image:Plasmacytoma1.jpg | Plasmacytoma. (WC) | Image:Plasmacytoma1.jpg | Plasmacytoma. (WC) | ||
File:Plasmocytoma HE high mag.jpg | Skull base plasmacytoma, higher magnification (WC/jensflorian) | |||
File:Plasmocytoma_frozen_HE_x200.jpg | Plasmacytoma smear (WC/jensflorian) | |||
File:Plasmocytoma_smear_mann_x200.jpg | Leptomeningeal plasmacytoma, frozen section (WC/jensflorian) | |||
</gallery> | </gallery> | ||
www | =====www===== | ||
*[http://ashimagebank.hematologylibrary.org/cgi/content/full/2004/0126/100984 Various images (hematologylibrary.org)]. | *[http://ashimagebank.hematologylibrary.org/cgi/content/full/2004/0126/100984 Various images (hematologylibrary.org)]. | ||
*[http://path.upmc.edu/cases/case515/images/fig05.jpg Multiple myeloma (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case515.html http://path.upmc.edu/cases/case515.html]. Accessed on: 25 January 2012.</ref> | *[http://path.upmc.edu/cases/case515/images/fig05.jpg Multiple myeloma (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case515.html http://path.upmc.edu/cases/case515.html]. Accessed on: 25 January 2012.</ref> | ||
| Line 63: | Line 105: | ||
Image:Russell_bodies_2_high_mag_mini.jpg | Russell bodies. (WC) | Image:Russell_bodies_2_high_mag_mini.jpg | Russell bodies. (WC) | ||
</gallery> | </gallery> | ||
www | =====www===== | ||
*[http://www.healthsystem.virginia.edu/internet/hematology/hessimages/russell-bodies-website-arrow.jpg Russell bodies (healthsystem.virginia.edu)]. | *[http://www.healthsystem.virginia.edu/internet/hematology/hessimages/russell-bodies-website-arrow.jpg Russell bodies (healthsystem.virginia.edu)]. | ||
*[http://www.pathguy.com/lectures/russ2.jpg Russell bodies - several in one cell (pathguy.com)]. | *[http://www.pathguy.com/lectures/russ2.jpg Russell bodies - several in one cell (pathguy.com)]. | ||
====Dutcher bodies==== | ====Dutcher bodies==== | ||
<gallery> | |||
Image: Dutcher and Russell bodies.jpg | Dutcher bodies and Russell bodies. (WC/Gabriel Caponetti) | |||
</gallery> | |||
==IHC== | ==IHC== | ||
*[[CD138]] +ve. | |||
*[[CD56]] +ve.<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/116930 http://www.ncbi.nlm.nih.gov/omim/116930]. Accessed on: 31 August 2010.</ref> | |||
**Also +ve in NK/T cell lymphomas. | |||
*Kappa -- usu. slightly stronger than lambda. | *Kappa -- usu. slightly stronger than lambda. | ||
*Lambda. | *Lambda. | ||
*CD57. | *CD57. | ||
**Also +ve in [[T-cell large granular lymphocytic leukemia]].<ref>URL: [http://www.nature.com/bmt/journal/v33/n1/full/1704298a.html http://www.nature.com/bmt/journal/v33/n1/full/1704298a.html]. Accessed on: 31 August 2010.</ref> | **Also +ve in [[T-cell large granular lymphocytic leukemia]].<ref>URL: [http://www.nature.com/bmt/journal/v33/n1/full/1704298a.html http://www.nature.com/bmt/journal/v33/n1/full/1704298a.html]. Accessed on: 31 August 2010.</ref> | ||
* | *CD38 +ve.<ref>{{Cite journal | last1 = Tamamori | first1 = T. | last2 = Nakayama | first2 = F. | last3 = Sugimoto | first3 = H. | last4 = Fenxiang | first4 = J. | last5 = Iwatsuki | first5 = K. | last6 = Takigawa | first6 = M. | title = Extramedullary plasmacytoma: cytological and genotypic studies. | journal = Br J Dermatol | volume = 129 | issue = 4 | pages = 468-72 | month = Oct | year = 1993 | doi = | PMID = 8217765 }}</ref> | ||
* | |||
Others:<ref>URL: [http://e-immunohistochemistry.info/web/Plasmacytoma_plasma_cell_myeloma.htm http://e-immunohistochemistry.info/web/Plasmacytoma_plasma_cell_myeloma.htm]. Accessed on: 9 November 2015.</ref> | |||
*CD79a +ve. | |||
*CD45 -ve/+ve. | |||
*CD10 -ve. | |||
*CD5 -ve. | |||
*Cyclin D1 -ve/+ve. | |||
A panel:<!-- need a good panel - maybe here http://clincancerres.aacrjournals.org/content/15/2/714.full or here http://e-immunohistochemistry.info/web/Plasmacytoma_plasma_cell_myeloma.htm --> | |||
*CD3, CD20, CD56, CD117, CD138, IG-kappa (plasma), IG-lambda (plasma). | |||
==Molecular== | ==Molecular== | ||