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'''POU domain, class 1, transcription factor 1''' (growth hormone factor 1), also known as POU1F1, abbreviated '''Pit1''', is a | '''POU domain, class 1, transcription factor 1''' (growth hormone factor 1), also known as POU1F1, abbreviated '''Pit1''', is a [[immunostain]] used endocrinology. | ||
==General== | ==General== | ||
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==Positive== | ==Positive== | ||
Pit-1 lineage pituitary tumors:<ref>{{Cite journal | last1 = Lloyd | first1 = RV. | last2 = Osamura | first2 = RY. | title = Transcription factors in normal and neoplastic pituitary tissues. | journal = Microsc Res Tech | volume = 39 | issue = 2 | pages = 168-81 | month = Oct | year = 1997 | doi = 10.1002/(SICI)1097-0029(19971015)39:2<168::AID-JEMT8>3.0.CO;2-H | PMID = 9361268 }}</ref> | |||
* Somatotroph adenoma. | * Somatotroph adenoma. | ||
* Lactotroph adenoma. | * Lactotroph adenoma. | ||
* Thyreotropha adenoma. | * Thyreotropha adenoma. | ||
* Mammary gland.<ref>{{Cite journal | last1 = Sendon-Lago | first1 = J. | last2 = Seoane | first2 = S. | last3 = Eiro | first3 = N. | last4 = Bermudez | first4 = MA. | last5 = Macia | first5 = M. | last6 = Garcia-Caballero | first6 = T. | last7 = Vizoso | first7 = FJ. | last8 = Perez-Fernandez | first8 = R. | title = Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of metalloproteinase (MMP)-13. | journal = Breast Cancer Res | volume = 16 | issue = 6 | pages = 505 | month = Dec | year = 2014 | doi = 10.1186/s13058-014-0505-8 | PMID = 25527274 }}</ref> | |||
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==Negative== | ==Negative== | ||
* Corticotroph adenoma. | |||
* Gonadotroph adenoma. | |||
* Null cell adenoma. | |||
==See also== | ==See also== | ||