Difference between revisions of "Penis"

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DDx - general:
DDx - general:
*[[Squamous cell carcinoma]] - nuclear atypia.
*[[Squamous cell carcinoma]] - nuclear atypia.
*[[Balanitis xerotica obliterans]] - supeficial dermal fibrosis with thinned epidermis.
*[[Lichen sclerosus]] - supeficial dermal fibrosis with thinned epidermis.
*[[Lichen planus]] - interface dermatitis with apoptotic bodies.
*[[Lichen planus]] - interface dermatitis with apoptotic bodies.
*Infection.
*Infection.

Revision as of 12:04, 18 March 2014

The penis is occasionally afflicted by disease that the pathologist see.

It is afflicted by common skin pathologies.

Normal

  • Corpus spongiosum - fills with blood during erection.[1]
  • Corpus cavernosum - around the urethra.

Image

Diseases

Inflammatory

Infectious

Other non-tumour

Pre-cancerous

Neoplastic

Others:

Specific conditions

Phimosis

General

  • Cannot retract foreskin.
  • This is a clinical diagnosis.

Microscopic

Features:[2]

  • +/-Inflammation.
  • Fibrosis.

Notes: Findings non-specific.

DDx - general:

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FORESKIN, CIRCUMCISION:
- SKIN WITH PATCHY MILD NONSPECIFIC INFLAMMATION.
- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY.
FORESKIN, EXCISION:
- KERATINIZED SQUAMOUS EPITHELIUM WITH PATCHY MILD NON-SPECIFIC
  SUBEPITHELIAL INFLAMMATION.
- NEGATIVE FOR MALIGNANCY.
FORESKIN, CIRCUMCISION:
- BENIGN KERATINIZED SQUAMOUS EPITHELIUM.
- MILDLY FIBROUS SUBEPITHELIAL TISSUE WITH MINIMAL PATCHY NONSPECIFIC INFLAMMATION.
- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY.

Micro

The sections show skin with mild patchy chronic inflammation, consisting predominantly of lymphocytes, at the dermal-epidermal junction. The epidermis matures to the surface, has rete ridges and is of a normal thickness. Focally, parakeratosis is present. No significant nuclear atypia is identified.

Thinned epidermis

The sections show skin with mild patchy chronic inflammation, consisting predominantly of lymphocytes, at the dermal-epidermal junction. Eosinophils are not readily apparent.

The epidermis matures to the surface; however, it is thinned and focally flattened appearing. No hyperkeratosis or parakeratosis is apparent. The superficial dermis is minimally hyalinized focally. No significant nuclear atypia is identified.

Penile fibromatosis

  • AKA Peyronie's disease.

General

  • Prevalence ~5%.[3]

Treatment:

  • Conservative versus surgery.

Gross

  • Abnormal curvature of the penis, esp. in the erect state.

Microscopic

Features:[3]

  • Tunica albuginea fibrosis.

Zoon balanitis

  • AKA balanitis circumscripta plasmacellularis.[4]
  • AKA plasma cell balanitis.[5]

General

Treatment:[6]

  • Circumcision.
  • Corticosteroids.

Microscopic

Features:[4]

DDx:

Images

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PENILE FORESKIN, CIRCUMCISION:
- COMPATIBLE WITH PLASMA CELL BALANITIS (ZOON BALANITIS), SEE COMMENT.

COMMENT:
A treponemal infection should be considered clinically.

Squamous cell carcinoma of the penis

See also

References

  1. Zhang, XH.; Melman, A.; Disanto, ME. (Jul 2011). "Update on corpus cavernosum smooth muscle contractile pathways in erectile function: a role for testosterone?". J Sex Med 8 (7): 1865-79. doi:10.1111/j.1743-6109.2011.02218.x. PMID 21324096.
  2. Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 391. ISBN 978-0781765275.
  3. 3.0 3.1 Serefoglu, EC.; Hellstrom, WJ. (Dec 2011). "Treatment of Peyronie's disease: 2012 update.". Curr Urol Rep 12 (6): 444-52. doi:10.1007/s11934-011-0212-2. PMID 21818660.
  4. 4.0 4.1 4.2 Balato, N.; Scalvenzi, M.; La Bella, S.; Di Costanzo, L. (2009). "Zoon's Balanitis: Benign or Premalignant Lesion?". Case Rep Dermatol 1 (1): 7-10. doi:10.1159/000210440. PMID 20652106.
  5. Korenaga, D.; Kanematsu, T.; Watanabe, A.; Maehara, Y.; Kitano, S.; Sugimachi, K. (Feb 1991). "Clinical management of gastric cancer and concomitant esophagogastric varices.". J Surg Oncol 46 (2): 91-6. PMID 1992223.
  6. 6.0 6.1 Yoganathan, S.; Bohl, TG.; Mason, G. (Dec 1994). "Plasma cell balanitis and vulvitis (of Zoon). A study of 10 cases.". J Reprod Med 39 (12): 939-44. PMID 7884748.

External links