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Difference between revisions of "Pediatric pathology"
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→Juvenile xanthogranuloma
(→IHC) |
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===IHC=== | ===IHC=== | ||
Features: | Features:<ref name=emed_jxg/> | ||
*Langerhans cell markers: CD1a, CD207 -- both should be negative. | *Langerhans cell markers: CD1a, CD207 -- both should be negative. | ||
**If Touton giant cells are absent -- this is essential. | **If Touton giant cells are absent -- this is essential. | ||
*Histiocyte markers: CD68, CD163 -- both should be positive. | *Histiocyte markers: CD68, CD163 -- both should be positive. | ||
*Vimentin +ve. | *Vimentin +ve. | ||
Negatives:<ref name=pmid9790615>{{cite journal |author=Thomas DB, Sidler AK, Huston BM |title=Radiological case of the month. Juvenile xanthogranuloma |journal=Arch Pediatr Adolesc Med |volume=152 |issue=10 |pages=1029–30 |year=1998 |month=October |pmid=9790615 |doi= |url=http://archpedi.ama-assn.org/cgi/content/full/152/10/1029}}</ref> | Negatives:<ref name=pmid9790615>{{cite journal |author=Thomas DB, Sidler AK, Huston BM |title=Radiological case of the month. Juvenile xanthogranuloma |journal=Arch Pediatr Adolesc Med |volume=152 |issue=10 |pages=1029–30 |year=1998 |month=October |pmid=9790615 |doi= |url=http://archpedi.ama-assn.org/cgi/content/full/152/10/1029}}</ref> | ||