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Papillary renal neoplasm with reverse polarity (view source)
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'''Papillary renal neoplasm with reverse polarity''' is a rare [[renal tumour]] and evolving entity.<ref name=pmid31135486>{{cite journal |authors=Al-Obaidy KI, Eble JN, Cheng L, Williamson SR, Sakr WA, Gupta N, Idrees MT, Grignon DJ |title=Papillary Renal Neoplasm With Reverse Polarity: A Morphologic, Immunohistochemical, and Molecular Study |journal=Am J Surg Pathol |volume=43 |issue=8 |pages=1099–1111 |date=August 2019 |pmid=31135486 |doi=10.1097/PAS.0000000000001288 |url=}}</ref> | '''Papillary renal neoplasm with reverse polarity''' is a rare [[renal tumour]] and evolving entity.<ref name=pmid31135486>{{cite journal |authors=Al-Obaidy KI, Eble JN, Cheng L, Williamson SR, Sakr WA, Gupta N, Idrees MT, Grignon DJ |title=Papillary Renal Neoplasm With Reverse Polarity: A Morphologic, Immunohistochemical, and Molecular Study |journal=Am J Surg Pathol |volume=43 |issue=8 |pages=1099–1111 |date=August 2019 |pmid=31135486 |doi=10.1097/PAS.0000000000001288 |url=}}</ref> | ||
==General== | |||
*Evolving entity. | |||
*Subset of ''[[papillary renal cell carcinoma]]''. | |||
==Micro== | |||
Features:<ref name=pmid31135486/> | |||
*Branching papillae with: | |||
**Thin fibrovascular cores. | |||
**Cuboidal to columnar lining cells with granular eosinophilic cytoplasm. | |||
***May have occasional cytoplasmic clearing. | |||
**Smooth luminal borders. | |||
**Reverse polarized nuclei (luminal nuclei; nuclei closer to lumen than basement membrane). | |||
**Nucleoli absent or small. | |||
DDx: | |||
*[[Renal tumours with eosinophilic cytoplasm]]. | |||
==IHC== | |||
Features:<ref name=pmid31135486/> | |||
*CK7 +ve. | |||
*CD10 +ve (all cases). | |||
*GATA3 +ve (all cases). | |||
*Vimentin -ve (all cases). | |||
*CD117 -ve. | |||
*AE1/AE3 +ve. | |||
*EMA +ve. | |||
*L1CAM +ve. | |||
==See also== | ==See also== | ||