Difference between revisions of "Panniculitis"
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===Microscopic=== | ===Microscopic=== | ||
Features:<ref name=Ref_PBoD8_1199>{{Ref PBoD8|1199}}</ref> | Features:<ref name=Ref_PBoD8_1199>{{Ref PBoD8|1199}}</ref><ref name=Ref_PCPBoD8_609>{{Ref PCPBoD8|609}}</ref> | ||
*Expanded ( | *Expanded septa between fat lobules - '''key (low power) feature'''. | ||
*[[Neutrophil]]s. | *[[Neutrophil]]s. | ||
*Lymphocytes. | |||
*Histiocytes. | |||
*Fibrin. | *Fibrin. | ||
Notes: | Notes: | ||
#No [[vasculitis]]. | |||
#+/-Granulomas.<ref name=uscf_en>URL: [http://missinglink.ucsf.edu/lm/DermatologyGlossary/erythema_nodosum.html http://missinglink.ucsf.edu/lm/DermatologyGlossary/erythema_nodosum.html]. Accessed on: 11 September 2011.</ref> | |||
Images: | |||
*[http://missinglink.ucsf.edu/lm/DermatologyGlossary/img/Dermatology%20Glossary/Glossary%20Histo%20Images/Erythema_Nodosum_low_power.jpg EN - low mag. (ucsf.edu)].<ref name=uscf_en>URL: [http://missinglink.ucsf.edu/lm/DermatologyGlossary/erythema_nodosum.html http://missinglink.ucsf.edu/lm/DermatologyGlossary/erythema_nodosum.html]. Accessed on: 11 September 2011.</ref> | |||
*[http://missinglink.ucsf.edu/lm/DermatologyGlossary/img/Dermatology%20Glossary/Glossary%20Histo%20Images/Erythema_Nodosum_high_power.jpg EN - high mag. (ucsf.edu)]. | |||
==Erythema induratum== | ==Erythema induratum== | ||
Revision as of 04:33, 11 September 2011
Panniculitis is inflammation of the adipose tissue. It is encountered in dermatopathology specimens.
General DDx
- Erythema nodosum.
- Erythema induratum.
- Self-inflicted trauma.
- Systemic lupus erythematosus.
- Weird stuff.
Specific conditions
Erythema nodosum
- Most common from of panniculitis.[1]
Causes - mnemonic NODOSUM:[1]
- NO cause (idiopathic) ~ 55% of cases.
- Drugs (sulfonamides, amoxicillin, oral contraceptives) ~ 5% of cases.
- Other infections - group A streptococci (streptococcal pharyngitis), Yersinia, chlamydia, mycobacteria, others ~ 30% of cases.
- Sarcoidosis ~ 7% of cases.
- Ulcerative colitis & Crohn's disease ~ 2% of cases.
- Malignancy (leukemia, Hodgkin's lymphoma) ~ 1% of cases
Microscopic
- Expanded septa between fat lobules - key (low power) feature.
- Neutrophils.
- Lymphocytes.
- Histiocytes.
- Fibrin.
Notes:
- No vasculitis.
- +/-Granulomas.[4]
Images:
Erythema induratum
General
Features:[2]
- Not common.
- Etiology: unknown.
Microscopic
Features:[2]
- Necrotizing granulomatous inflammation.
- Necrotizing vasculitis of small/medium sized vessels (early).
DDx:
- Infection.
See also
References
- ↑ 1.0 1.1 Schwartz, RA.; Nervi, SJ. (Mar 2007). "Erythema nodosum: a sign of systemic disease.". Am Fam Physician 75 (5): 695-700. PMID 17375516.
- ↑ 2.0 2.1 2.2 Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1199. ISBN 978-1416031215.
- ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 609. ISBN 978-1416054542.
- ↑ 4.0 4.1 URL: http://missinglink.ucsf.edu/lm/DermatologyGlossary/erythema_nodosum.html. Accessed on: 11 September 2011.