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Difference between revisions of "POEMS syndrome"
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Diagnostic criteria requires both mandatory criteria and at least one each from major and minor criteria:<ref name=pmid31012139>{{cite journal |vauthors=Dispenzieri A |title=POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management |journal=Am. J. Hematol. |volume=94 |issue=7 |pages=812–827 |date=July 2019 |pmid=31012139 |doi=10.1002/ajh.25495 |url=}}</ref> | Diagnostic criteria requires both mandatory criteria and at least one each from major and minor criteria:<ref name=pmid31012139>{{cite journal |vauthors=Dispenzieri A |title=POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management |journal=Am. J. Hematol. |volume=94 |issue=7 |pages=812–827 |date=July 2019 |pmid=31012139 |doi=10.1002/ajh.25495 |url=}}</ref> | ||
Mandatory: | ''Mandatory:'' | ||
1. Polyneuropathy (typically demyelinating) | ;1. Polyneuropathy (typically demyelinating) | ||
2. Monoclonal plasma cell proliferation (usually lambda) | ;2. Monoclonal plasma cell proliferation (usually lambda) | ||
Major: | ''Major:'' | ||
3. [[Castleman disease]] | ;3. [[Castleman disease]] | ||
4. Sclerotic bone lesions | ;4. Sclerotic bone lesions | ||
5. Vascular endothelial growth factor elevation | ;5. Vascular endothelial growth factor elevation | ||
Minor: | ''Minor:'' | ||
6. Organomegaly (splenomegaly, hepatomegaly or lymphadenopathy) | ;6. Organomegaly (splenomegaly, hepatomegaly or lymphadenopathy) | ||
7. Extravascular volume overload | ;7. Extravascular volume overload | ||
8. Endocrinopathy | ;8. Endocrinopathy | ||
9. Sking changes | ;9. Sking changes | ||
10. Papilloedema | ;10. Papilloedema | ||
11. Thrombocytosis/polycythemia | ;11. Thrombocytosis/polycythemia | ||
POEMS syndrome is unusual in causing osteosclerotic bone deposits, so-called osteosclerotic myeloma, in contrast to the lytic lesions seen in more conventional [[plasma cell myeloma]]. | POEMS syndrome is unusual in causing osteosclerotic bone deposits, so-called osteosclerotic myeloma, in contrast to the lytic lesions seen in more conventional [[plasma cell myeloma]]. | ||