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m (typically osteosclerotic) |
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''Mandatory:'' | ''Mandatory:'' | ||
# Polyneuropathy (typically demyelinating) | # Polyneuropathy (typically demyelinating). | ||
# Monoclonal plasma cell proliferation (usually lambda) | # Monoclonal plasma cell proliferation (usually lambda). | ||
''Major:'' | ''Major:'' | ||
# [[Castleman disease]] | # [[Castleman disease]] | ||
# Sclerotic bone lesions | # Sclerotic bone lesions. | ||
# Vascular endothelial growth factor elevation | # Vascular endothelial growth factor elevation. | ||
''Minor:'' | ''Minor:'' | ||
# Organomegaly (splenomegaly, hepatomegaly or lymphadenopathy) | # Organomegaly (splenomegaly, hepatomegaly or lymphadenopathy). | ||
# Extravascular volume overload | # Extravascular volume overload. | ||
# Endocrinopathy | # Endocrinopathy. | ||
# | # Skin changes. | ||
# Papilloedema | # Papilloedema. | ||
# Thrombocytosis/polycythemia | # Thrombocytosis/polycythemia. | ||
==Pathology== | ==Pathology== | ||
*The [[pathologist]] may come across an undiagnosed case in the form of a ''[[glomeruloid hemangioma]]''; however, glomeruloid [[hemangioma]]s are not always associated with the POEMS syndrome.<ref name=pmid19077091>{{cite journal |author=González-Guerra E, Haro MR, Fariña MC, Martín L, Manzarbeitia L, Requena L |title=Glomeruloid haemangioma is not always associated with POEMS syndrome |journal=Clin. Exp. Dermatol. |volume=34 |issue=7 |pages=800–3 |year=2009 |month=October |pmid=19077091 |doi=10.1111/j.1365-2230.2008.02997.x |url=}}</ref> | *The [[pathologist]] may come across an undiagnosed case in the form of a ''[[glomeruloid hemangioma]]''; however, glomeruloid [[hemangioma]]s are not always associated with the POEMS syndrome.<ref name=pmid19077091>{{cite journal |author=González-Guerra E, Haro MR, Fariña MC, Martín L, Manzarbeitia L, Requena L |title=Glomeruloid haemangioma is not always associated with POEMS syndrome |journal=Clin. Exp. Dermatol. |volume=34 |issue=7 |pages=800–3 |year=2009 |month=October |pmid=19077091 |doi=10.1111/j.1365-2230.2008.02997.x |url=}}</ref> | ||
*POEMS syndrome typically cause osteosclerotic bone deposits (so-called osteosclerotic myeloma), in contrast to the lytic lesions seen in more conventional [[plasma cell myeloma]].{{fact}} | |||
==See also== | ==See also== |
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