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Difference between revisions of "P40"
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{{ Infobox immunostain | {{ Infobox immunostain | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Consistent with HPV-associated SCC - p40 -- high mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = p40 immunostain in [[squamous cell carcinoma]]. | ||
| Abbrev = | | Abbrev = | ||
| Synonyms = | | Synonyms = | ||
| Similar = p63 | | Similar = [[p63]] - less specific for [[squamous carcinoma]] than p40 | ||
| Clones = | | Clones = | ||
| Use = lung (adenocarcinoma vs. squamous) | | Use = lung (adenocarcinoma vs. squamous) | ||
| Line 12: | Line 12: | ||
| Pattern = nuclear staining | | Pattern = nuclear staining | ||
| Positive = [[squamous cell carcinoma]], [[urothelial carcinoma]] | | Positive = [[squamous cell carcinoma]], [[urothelial carcinoma]] | ||
| Negative = [[prostate carcinoma]], most [[lung adenocarcinoma]], breast carcinoma | | Negative = [[prostate carcinoma]], most [[lung adenocarcinoma]], most breast carcinoma | ||
| Other = | | Other = | ||
}} | }} | ||
'''p40''' an [[immunostain]] that is both [[sensitivity|sensitive]] and [[specificity|specific]] for [[squamous cell carcinoma]]. | '''p40''' an [[immunostain]] that is both [[sensitivity|sensitive]] and [[specificity|specific]] for [[squamous cell carcinoma]]. Like other "p" immunostains (e.g. p16, p63), it is a nuclear stain. | ||
==General== | ==General== | ||
*Considered superior to [[p63]] as it is more [[specificity|specific]].<ref name=pmid22056955>{{Cite journal | last1 = Bishop | first1 = JA. | last2 = Teruya-Feldstein | first2 = J. | last3 = Westra | first3 = WH. | last4 = Pelosi | first4 = G. | last5 = Travis | first5 = WD. | last6 = Rekhtman | first6 = N. | title = p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma. | journal = Mod Pathol | volume = 25 | issue = 3 | pages = 405-15 | month = Mar | year = 2012 | doi = 10.1038/modpathol.2011.173 | PMID = 22056955 }}</ref> | *Considered superior to [[p63]] as it is more [[specificity|specific]].<ref name=pmid22056955>{{Cite journal | last1 = Bishop | first1 = JA. | last2 = Teruya-Feldstein | first2 = J. | last3 = Westra | first3 = WH. | last4 = Pelosi | first4 = G. | last5 = Travis | first5 = WD. | last6 = Rekhtman | first6 = N. | title = p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma. | journal = Mod Pathol | volume = 25 | issue = 3 | pages = 405-15 | month = Mar | year = 2012 | doi = 10.1038/modpathol.2011.173 | PMID = 22056955 }}</ref><ref name=pmid25263848>{{Cite journal | last1 = Alomari | first1 = AK. | last2 = Glusac | first2 = EJ. | last3 = McNiff | first3 = JM. | title = p40 is a more specific marker than p63 for cutaneous poorly differentiated squamous cell carcinoma. | journal = J Cutan Pathol | volume = 41 | issue = 11 | pages = 839-45 | month = Nov | year = 2014 | doi = 10.1111/cup.12388 | PMID = 25263848 }}</ref> | ||
**p63 stains a significant number of adenocarcinoma. | **p63 stains a significant number of [[adenocarcinoma]]s. | ||
==Staining== | ==Staining== | ||
| Line 26: | Line 26: | ||
*[[Urothelial carcinoma]].<ref name=pmid24711443>{{Cite journal | last1 = Brandler | first1 = TC. | last2 = Aziz | first2 = MS. | last3 = Rosen | first3 = LM. | last4 = Bhuiya | first4 = TA. | last5 = Yaskiv | first5 = O. | title = Usefulness of GATA3 and p40 immunostains in the diagnosis of metastatic urothelial carcinoma in cytology specimens. | journal = Cancer Cytopathol | volume = 122 | issue = 6 | pages = 468-73 | month = Jun | year = 2014 | doi = 10.1002/cncy.21424 | PMID = 24711443 }}</ref> | *[[Urothelial carcinoma]].<ref name=pmid24711443>{{Cite journal | last1 = Brandler | first1 = TC. | last2 = Aziz | first2 = MS. | last3 = Rosen | first3 = LM. | last4 = Bhuiya | first4 = TA. | last5 = Yaskiv | first5 = O. | title = Usefulness of GATA3 and p40 immunostains in the diagnosis of metastatic urothelial carcinoma in cytology specimens. | journal = Cancer Cytopathol | volume = 122 | issue = 6 | pages = 468-73 | month = Jun | year = 2014 | doi = 10.1002/cncy.21424 | PMID = 24711443 }}</ref> | ||
====Images==== | |||
<gallery> | |||
Image: Consistent with HPV-associated SCC - p40 -- intermed mag.jpg | c/w HPV-SCC - p40 - intermed. mag. (WC/Nephron) | |||
Image: Consistent with HPV-associated SCC - p40 -- high mag.jpg | c/w HPV-SCC - p40 - high mag. (WC/Nephron) | |||
</gallery> | |||
===Negative=== | ===Negative=== | ||
*[[Lung adenocarcinoma]]. | *[[Lung adenocarcinoma]]. | ||
*Breast carcinoma. | *Breast carcinoma. | ||
**CK5 +ve breast | **CK5 +ve breast carcinomas are typically p40 positive.<ref name=pmid26330357>{{Cite journal | last1 = Kővári | first1 = B. | last2 = Szász | first2 = AM. | last3 = Kulka | first3 = J. | last4 = Marušić | first4 = Z. | last5 = Šarčević | first5 = B. | last6 = Tiszlavicz | first6 = L. | last7 = Cserni | first7 = G. | title = Evaluation of p40 as a Myoepithelial Marker in Different Breast Lesions. | journal = Pathobiology | volume = 82 | issue = 3-4 | pages = 166-71 | month = Sep | year = 2015 | doi = 10.1159/000375127 | PMID = 26330357 }}</ref> | ||
*[[Prostate carcinoma]].<ref name=pmid25852959>{{Cite journal | last1 = Brustmann | first1 = H. | title = p40 as a Basal Cell Marker in the Diagnosis of Prostate Glandular Proliferations: A Comparative Immunohistochemical Study with 34betaE12. | journal = Patholog Res Int | volume = 2015 | issue = | pages = 897927 | month = | year = 2015 | doi = 10.1155/2015/897927 | PMID = 25852959 }}</ref> | |||
==See also== | ==See also== | ||