Difference between revisions of "P40"
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*Breast carcinoma. | *Breast carcinoma. | ||
**CK5 +ve breast carcinomas are typically p40 positive.<ref name=pmid26330357>{{Cite journal | last1 = Kővári | first1 = B. | last2 = Szász | first2 = AM. | last3 = Kulka | first3 = J. | last4 = Marušić | first4 = Z. | last5 = Šarčević | first5 = B. | last6 = Tiszlavicz | first6 = L. | last7 = Cserni | first7 = G. | title = Evaluation of p40 as a Myoepithelial Marker in Different Breast Lesions. | journal = Pathobiology | volume = 82 | issue = 3-4 | pages = 166-71 | month = Sep | year = 2015 | doi = 10.1159/000375127 | PMID = 26330357 }}</ref> | **CK5 +ve breast carcinomas are typically p40 positive.<ref name=pmid26330357>{{Cite journal | last1 = Kővári | first1 = B. | last2 = Szász | first2 = AM. | last3 = Kulka | first3 = J. | last4 = Marušić | first4 = Z. | last5 = Šarčević | first5 = B. | last6 = Tiszlavicz | first6 = L. | last7 = Cserni | first7 = G. | title = Evaluation of p40 as a Myoepithelial Marker in Different Breast Lesions. | journal = Pathobiology | volume = 82 | issue = 3-4 | pages = 166-71 | month = Sep | year = 2015 | doi = 10.1159/000375127 | PMID = 26330357 }}</ref> | ||
*[[Prostate carcinoma]].<ref name=pmid25852959>{{Cite journal | last1 = Brustmann | first1 = H. | title = p40 as a Basal Cell Marker in the Diagnosis of Prostate Glandular Proliferations: A Comparative Immunohistochemical Study with 34betaE12. | journal = Patholog Res Int | volume = 2015 | issue = | pages = 897927 | month = | year = 2015 | doi = 10.1155/2015/897927 | PMID = 25852959 }}</ref> | |||
==See also== | ==See also== | ||
Revision as of 17:34, 20 December 2016
| P40 | |
|---|---|
| Immunostain in short | |
| Similar stains | p63 |
| Use | lung (adenocarcinoma vs. squamous) |
| Normal staining pattern | nuclear staining |
| Positive | squamous cell carcinoma, urothelial carcinoma |
| Negative | prostate carcinoma, most lung adenocarcinoma, most breast carcinoma |
p40 an immunostain that is both sensitive and specific for squamous cell carcinoma. Like other "p" immunostains (e.g. p16, p63), it is a nuclear stain.
General
- Considered superior to p63 as it is more specific.[1]
- p63 stains a significant number of adenocarcinoma.
Staining
Positive
Negative
- Lung adenocarcinoma.
- Breast carcinoma.
- CK5 +ve breast carcinomas are typically p40 positive.[3]
- Prostate carcinoma.[4]
See also
- p63.
References
- ↑ Bishop, JA.; Teruya-Feldstein, J.; Westra, WH.; Pelosi, G.; Travis, WD.; Rekhtman, N. (Mar 2012). "p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma.". Mod Pathol 25 (3): 405-15. doi:10.1038/modpathol.2011.173. PMID 22056955.
- ↑ Brandler, TC.; Aziz, MS.; Rosen, LM.; Bhuiya, TA.; Yaskiv, O. (Jun 2014). "Usefulness of GATA3 and p40 immunostains in the diagnosis of metastatic urothelial carcinoma in cytology specimens.". Cancer Cytopathol 122 (6): 468-73. doi:10.1002/cncy.21424. PMID 24711443.
- ↑ Kővári, B.; Szász, AM.; Kulka, J.; Marušić, Z.; Šarčević, B.; Tiszlavicz, L.; Cserni, G. (Sep 2015). "Evaluation of p40 as a Myoepithelial Marker in Different Breast Lesions.". Pathobiology 82 (3-4): 166-71. doi:10.1159/000375127. PMID 26330357.
- ↑ Brustmann, H. (2015). "p40 as a Basal Cell Marker in the Diagnosis of Prostate Glandular Proliferations: A Comparative Immunohistochemical Study with 34betaE12.". Patholog Res Int 2015: 897927. doi:10.1155/2015/897927. PMID 25852959.