Difference between revisions of "P16"

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[[Image:High grade squamous intraepithelial lesion - 2 - p16 -- high mag.jpg|thumb|right|200px|HSIL showing the characteristic p16 staining.]]
[[Image:High grade squamous intraepithelial lesion - 2 - p16 -- high mag.jpg|thumb|right|250px|HSIL showing the characteristic p16 staining.]]
[[Image:Endocervical adenocarcinoma in situ - p16 --- high mag.jpg|thumb|right|AIS showing the characteristic p16 staining.]]
'''p16''' is a commonly used [[immunostain]].  It can be considered a surrogate marker for [[HPV]] infection.
'''p16''' is a commonly used [[immunostain]].  It can be considered a surrogate marker for [[HPV]] infection.
p16, like most other "p" stains, is a nuclear stain.  
p16, like most other "p" stains, is a nuclear stain.  

Revision as of 05:23, 5 June 2016

HSIL showing the characteristic p16 staining.
AIS showing the characteristic p16 staining.

p16 is a commonly used immunostain. It can be considered a surrogate marker for HPV infection. p16, like most other "p" stains, is a nuclear stain.

Pattern

  • Nuclear stain +/- cytoplasmic staining.

Use

Tumours

Positive

Negative

References

  1. Piaton, E.; Casalegno, JS.; Advenier, AS.; Decaussin-Petrucci, M.; Mege-Lechevallier, F.; Ruffion, A.; Mekki, Y. (Oct 2014). "p16(INK4a) overexpression is not linked to oncogenic human papillomaviruses in patients with high-grade urothelial cancer cells.". Cancer Cytopathol 122 (10): 760-9. doi:10.1002/cncy.21462. PMID 25069600.
  2. Pereira, TC.; Share, SM.; Magalhães, AV.; Silverman, JF. (Jan 2011). "Can we tell the site of origin of metastatic squamous cell carcinoma? An immunohistochemical tissue microarray study of 194 cases.". Appl Immunohistochem Mol Morphol 19 (1): 10-4. doi:10.1097/PAI.0b013e3181ecaf1c. PMID 20823766.

External links