Difference between revisions of "P16"

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*Squamous lesions of the [[uterine cervix]] - see [[HSIL]].
*Squamous lesions of the [[uterine cervix]] - see [[HSIL]].
*Head and neck squamous cell carcinoma, specifically ''[[human papillomavirus-associated head and neck squamous cell carcinoma]]''.
*Head and neck squamous cell carcinoma, specifically ''[[human papillomavirus-associated head and neck squamous cell carcinoma]]''.
==Tumours==
===Positive===
*Squamous cell carcinoma - esp. cervical SCC, anal SCC, penile SCC, HPV-associated head and neck SCC.
*High grade [[urothelial carcinoma]] ~86% of cases.<ref name=pmid25069600>{{Cite journal  | last1 = Piaton | first1 = E. | last2 = Casalegno | first2 = JS. | last3 = Advenier | first3 = AS. | last4 = Decaussin-Petrucci | first4 = M. | last5 = Mege-Lechevallier | first5 = F. | last6 = Ruffion | first6 = A. | last7 = Mekki | first7 = Y. | title = p16(INK4a) overexpression is not linked to oncogenic human papillomaviruses in patients with high-grade urothelial cancer cells. | journal = Cancer Cytopathol | volume = 122 | issue = 10 | pages = 760-9 | month = Oct | year = 2014 | doi = 10.1002/cncy.21462 | PMID = 25069600 }}</ref>
===Negative===
*Breast carcinoma.
*Prostate carcinoma.
*Lung squamous cell carcinoma.<ref name=pmid25069600/>


==External links==
==External links==

Revision as of 18:50, 12 March 2015

HSIL showing the characteristic p16 staining.

p16 is a commonly used immunostain. It can be considered a surrogate marker for HPV infection. p16, like most other "p" stains, is a nuclear stain.

Pattern

  • Nuclear stain +/- cytoplasmic staining.

Use

Tumours

Positive

  • Squamous cell carcinoma - esp. cervical SCC, anal SCC, penile SCC, HPV-associated head and neck SCC.
  • High grade urothelial carcinoma ~86% of cases.[1]

Negative

  • Breast carcinoma.
  • Prostate carcinoma.
  • Lung squamous cell carcinoma.[1]

External links

  1. 1.0 1.1 Piaton, E.; Casalegno, JS.; Advenier, AS.; Decaussin-Petrucci, M.; Mege-Lechevallier, F.; Ruffion, A.; Mekki, Y. (Oct 2014). "p16(INK4a) overexpression is not linked to oncogenic human papillomaviruses in patients with high-grade urothelial cancer cells.". Cancer Cytopathol 122 (10): 760-9. doi:10.1002/cncy.21462. PMID 25069600.