Ovary

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The ovary has a wealth of pathology. It has benign tumours and malignant ones.

Normal

  • Corpora albicans - pale/white body with lobulated contour.
  • Ovarian follicles.
  • Stroma - hyperchromatic - spindle morphology, whorling.
    • If the cells have a round morphology... think about endometriosis.

Micrograph

Cysts

General:

  • Very common.

Most common:

  • Serous cystadenoma.
    • Usually uniloculated.
    • Morphology: ciliated, columnar.
  • Mucinous cystadenoma.
    • Usually multiloculated.[1]
      • Memory device: multiloculated = mucinous.
  • Endometrioma (see endometriosis).
  • Simple cyst.
  • Cancerous cyst (see ovarian cancer).

Notes

  • Epithelium is often lost in processing - may make interpretation challenging
  • Ovarian surface epithelium (previously call germinal epithelium) - covers the ovary
    • Cuboidal/flat epithelium.[2]
    • Has ovarian stroma underneath.
    • Nobnail morphology (free surface larger than basement membrane surface).[3]

Ovarian surface vs. mesothelium:

Endometriosis

Ovarian tumours

For a very brief overview of gynecologic tumours see: Gynecologic pathology.

Benign mesothelial inclusion cyst

Epidemiology

  • Assoc. with previous surgery.
  • May be found incidentally, e.g. during C-section.

Gross

  • May mimic mucinous tumour - to unexperienced.[4]
  • Thin-wall.[5]
  • Clear/translucent fluid.

Microscopic

Features:

  • Benign mesothelium.
    • Single layer of squamoid or cuboid mesothelial cells.[5]

IHC

See also

References

  1. IAV. 6 February 2009.
  2. Auersperg N, Wong AS, Choi KC, Kang SK, Leung PC (April 2001). "Ovarian surface epithelium: biology, endocrinology, and pathology". Endocr. Rev. 22 (2): 255–88. PMID 11294827. http://edrv.endojournals.org/cgi/pmidlookup?view=long&pmid=11294827.
  3. ALS. 5 February 2009.
  4. GAG 26 Feb 2009.
  5. 5.0 5.1 5.2 Urbanczyk K, Skotniczny K, Kucinski J, Friediger J (2005). "Mesothelial inclusion cysts (so-called benign cystic mesothelioma)--a clinicopathological analysis of six cases". Pol J Pathol 56 (2): 81-7. PMID 16092670.