Difference between revisions of "Ovarian microcystic stromal tumour"

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{{ Infobox diagnosis
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Name      = {{PAGENAME}}
| Image      =  
| Image      = Microcystic stromal tumour of ovary -- intermed mag.jpg
| Width      =
| Width      =
| Caption    =  
| Caption    = Microcystic stromal tumour of ovary. [[H&E stain]].
| Synonyms  =
| Synonyms  =
| Micro      = microscopic cysts alternating with solid cellular regions, hyalinized fibrous stroma
| Micro      = microscopic cysts alternating with solid cellular regions, hyalinized fibrous stroma
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| Prognosis  = unknown
| Prognosis  = unknown
| Other      =
| Other      =
| ClinDDx    = other [[ovarian tumours]], [[testis|testicular tumours]]
| ClinDDx    = other [[ovarian tumours]], other [[testis|testicular tumours]]
| Tx        = excision
| Tx        = excision
}}
}}
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*Evolving entity.
*Evolving entity.
*Reported in the testis.<ref name=pmid29169232>{{Cite journal  | last1 = Zhu | first1 = P. | last2 = Duan | first2 = Y. | last3 = Ao | first3 = Q. | last4 = Wang | first4 = G. | title = Microcystic Stromal Tumor of Testicle: First Case Report and Literature Review. | journal = Cancer Res Treat | volume = 50 | issue = 4 | pages = 1452-1457 | month = Oct | year = 2018 | doi = 10.4143/crt.2017.414 | PMID = 29169232 }}</ref>
*Reported in the testis.<ref name=pmid29169232>{{Cite journal  | last1 = Zhu | first1 = P. | last2 = Duan | first2 = Y. | last3 = Ao | first3 = Q. | last4 = Wang | first4 = G. | title = Microcystic Stromal Tumor of Testicle: First Case Report and Literature Review. | journal = Cancer Res Treat | volume = 50 | issue = 4 | pages = 1452-1457 | month = Oct | year = 2018 | doi = 10.4143/crt.2017.414 | PMID = 29169232 }}</ref>
*[[Sex cord stromal tumour]].<ref name=pmid26200099>{{Cite journal  | last1 = Irving | first1 = JA. | last2 = Lee | first2 = CH. | last3 = Yip | first3 = S. | last4 = Oliva | first4 = E. | last5 = McCluggage | first5 = WG. | last6 = Young | first6 = RH. | title = Microcystic Stromal Tumor: A Distinctive Ovarian Sex Cord-Stromal Neoplasm Characterized by FOXL2, SF-1, WT-1, Cyclin D1, and β-catenin Nuclear Expression and CTNNB1 Mutations. | journal = Am J Surg Pathol | volume = 39 | issue = 10 | pages = 1420-6 | month = Oct | year = 2015 | doi = 10.1097/PAS.0000000000000482 | PMID = 26200099 }}</ref><ref name=pmid30014019>{{Cite journal  | last1 = Jeong | first1 = D. | last2 = Hakam | first2 = A. | last3 = Abuel-Haija | first3 = M. | last4 = Chon | first4 = HS. | title = Ovarian microcystic stromal tumor: Radiologic-pathologic correlation. | journal = Gynecol Oncol Rep | volume = 25 | issue =  | pages = 11-14 | month = Aug | year = 2018 | doi = 10.1016/j.gore.2018.05.004 | PMID = 30014019 }}</ref>


==Microscopic==
==Microscopic==
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*Microcysts alternating with solid cellular regions.
*Microcysts alternating with solid cellular regions.
*Hyalinized fibrous stroma.
*Hyalinized fibrous stroma.
DDx:
*Other [[sex cord stromal tumours]].


===Images===
===Images===

Latest revision as of 14:30, 16 October 2019

Ovarian microcystic stromal tumour (abbreviated MST), also microcystic stromal tumour of the ovary, is a rare ovarian tumour.

Ovarian microcystic stromal tumour
Diagnosis in short

Microcystic stromal tumour of ovary. H&E stain.
LM microscopic cysts alternating with solid cellular regions, hyalinized fibrous stroma
LM DDx other sex cord stromal tumours
IHC CD10 +ve (cytoplasmic), beta-catenin (nuclear) +ve, WT-1 +ve, cyclin D1 +ve, inhibin -ve, calretinin -ve, ER-, PR-
Site ovary, testis
Prevalence rare, evolving entity
Prognosis unknown
Clin. DDx other ovarian tumours, other testicular tumours
Treatment excision

General

Microscopic

Features:[4]

  • Microcysts alternating with solid cellular regions.
  • Hyalinized fibrous stroma.

DDx:

Images

  • MST - extremely low mag. (WC)

  • MST - very low mag. (WC)

  • MST - low mag. (WC)

  • MST - intermed. mag. (WC)

  • MST - high mag. (WC)

  • MST - high mag. (WC)

  • MST - very high mag. (WC)

IHC

Features:[4]

  • CD10 +ve (cytoplasmic).
  • Beta-catenin +ve (nuclear).
  • WT1 +ve.
  • Cyclin D1 +ve.
  • Inhibin -ve.
  • Calretinin -ve.
  • ER -ve.
  • PR -ve.

Molecular

  • CTNNB1 mutation.[5]

References

  1. ↑ Zhu, P.; Duan, Y.; Ao, Q.; Wang, G. (Oct 2018). "Microcystic Stromal Tumor of Testicle: First Case Report and Literature Review.". Cancer Res Treat 50 (4): 1452-1457. doi:10.4143/crt.2017.414. PMID 29169232.
  2. ↑ Irving, JA.; Lee, CH.; Yip, S.; Oliva, E.; McCluggage, WG.; Young, RH. (Oct 2015). "Microcystic Stromal Tumor: A Distinctive Ovarian Sex Cord-Stromal Neoplasm Characterized by FOXL2, SF-1, WT-1, Cyclin D1, and β-catenin Nuclear Expression and CTNNB1 Mutations.". Am J Surg Pathol 39 (10): 1420-6. doi:10.1097/PAS.0000000000000482. PMID 26200099.
  3. ↑ Jeong, D.; Hakam, A.; Abuel-Haija, M.; Chon, HS. (Aug 2018). "Ovarian microcystic stromal tumor: Radiologic-pathologic correlation.". Gynecol Oncol Rep 25: 11-14. doi:10.1016/j.gore.2018.05.004. PMID 30014019.
  4. ↑ 4.0 4.1 McCluggage, WG.; Chong, AS.; Attygalle, AD.; Clarke, BA.; Chapman, W.; Rivera, B.; Foulkes, WD. (Feb 2019). "Expanding the morphological spectrum of ovarian microcystic stromal tumour.". Histopathology 74 (3): 443-451. doi:10.1111/his.13755. PMID 30325056.
  5. ↑ Na, K.; Kim, EK.; Jang, W.; Kim, HS. (Jun 2017). "CTNNB1 Mutations in Ovarian Microcystic Stromal Tumors: Identification of a Novel Deletion Mutation and the Use of Pyrosequencing to Identify Reported Point Mutation.". Anticancer Res 37 (6): 3249-3258. doi:10.21873/anticanres.11688. PMID 28551672.
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