Difference between revisions of "Oncogene"

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'''Oncogene''' is a cancer gene, derived from a '''proto-oncogene'''.   
An '''oncogene''' is a [[cancer]] gene, derived from a '''proto-oncogene'''.   


Examples:
==Examples==
*EGFR<ref name=omim131550>{{OMIM|131550}}</ref> - [[lung adenocarcinoma]].
{| class="wikitable sortable"
*PDGFB<ref name=omim190040>{{OMIM|190040}}</ref> - [[dermatofibrosarcoma protuberans]].
! Gene
*BRAF.<ref name=omim164757>{{OMIM|164757}}</ref>
! Cancer
*KRAS.<ref name=omim190070>{{OMIM|190070}}</ref>
|-
*MYC<ref name=omim190080>{{OMIM|190080}}</ref> - [[Burkitt lymphoma]].
| EGFR<ref name=omim131550>{{OMIM|131550}}</ref>  
*MET<ref name=omim164860>{{OMIM|164860}}</ref> - [[papillary renal cell carcinoma]].
| [[lung adenocarcinoma]], [[glioblastoma]],<ref name=Ref_APBR419>{{Ref APBR|419 Q6}}</ref> [[anaplastic astrocytoma]]<ref name=Ref_APBR419>{{Ref APBR|419 Q6}}</ref>
|-
| PDGFB<ref name=omim190040>{{OMIM|190040}}</ref>  
| [[dermatofibrosarcoma protuberans]]
|-
| BRAF<ref name=omim164757>{{OMIM|164757}}</ref>  
| [[papillary thyroid carcinoma tall cell variant]]
|-
| [[KRAS mutation|KRAS]]<ref name=omim190070>{{OMIM|190070}}</ref>  
| [[invasive ductal carcinoma of the pancreas]]
|-
| MYC<ref name=omim190080>{{OMIM|190080}}</ref>  
| [[Burkitt lymphoma]]
|-
| MET<ref name=omim164860>{{OMIM|164860}}</ref>  
| [[papillary renal cell carcinoma]]
|-
| ERBB2 (HER2)<ref name=omim164870>{{OMIM|164870}}</ref>
| [[invasive breast carcinoma]]
|-
| CCND1 (BCL1)<ref name=omim168461>{{OMIM|168461}}</ref>
| [[mantle cell lymphoma]]
|-
| EWSR1<ref name=omim133450>{{OMIM|133450}}</ref>
| [[Ewing sarcoma]], [[clear cell sarcoma]], [[DSRCT]], [[extraskeletal myxoid chondrosarcoma|EMC]]
|}


==See also==
==See also==

Latest revision as of 12:07, 30 April 2014

An oncogene is a cancer gene, derived from a proto-oncogene.

Examples

Gene Cancer
EGFR[1] lung adenocarcinoma, glioblastoma,[2] anaplastic astrocytoma[2]
PDGFB[3] dermatofibrosarcoma protuberans
BRAF[4] papillary thyroid carcinoma tall cell variant
KRAS[5] invasive ductal carcinoma of the pancreas
MYC[6] Burkitt lymphoma
MET[7] papillary renal cell carcinoma
ERBB2 (HER2)[8] invasive breast carcinoma
CCND1 (BCL1)[9] mantle cell lymphoma
EWSR1[10] Ewing sarcoma, clear cell sarcoma, DSRCT, EMC

See also

References

  1. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 131550
  2. ↑ 2.0 2.1 Lefkowitch, Jay H. (2006). Anatomic Pathology Board Review (1st ed.). Saunders. pp. 419 Q6. ISBN 978-1416025887.
  3. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 190040
  4. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 164757
  5. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 190070
  6. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 190080
  7. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 164860
  8. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 164870
  9. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 168461
  10. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 133450
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