Difference between revisions of "Nucleus-to-cytoplasm ratio"

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'''Nucleus-to-cytoplasm ratio''', also '''nuclear-cytoplasmic ratio''', is the relative size of the nucleus to the cytoplasm.  It is commonly abbreviated '''NC ratio'''.
'''Nucleus-to-cytoplasm ratio''', also '''nuclear-cytoplasmic ratio''', is the relative size of the nucleus to the cytoplasm.  It is commonly abbreviated '''NC ratio'''.


High NC ratio is strong predictor of [[malignancy]].<ref name=pmid16556320>{{Cite journal  | last1 = Mehrotra | first1 = R. | last2 = Gupta | first2 = A. | last3 = Singh | first3 = M. | last4 = Ibrahim | first4 = R. | title = Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions. | journal = Mol Cancer | volume = 5 | issue =  | pages = 11 | month =  | year = 2006 | doi = 10.1186/1476-4598-5-11 | PMID = 16556320 | URL = http://www.biomedcentral.com/1476-4598/5/11 }}
High NC ratio is a strong predictor of [[malignancy]].<ref name=pmid16556320>{{Cite journal  | last1 = Mehrotra | first1 = R. | last2 = Gupta | first2 = A. | last3 = Singh | first3 = M. | last4 = Ibrahim | first4 = R. | title = Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions. | journal = Mol Cancer | volume = 5 | issue =  | pages = 11 | month =  | year = 2006 | doi = 10.1186/1476-4598-5-11 | PMID = 16556320 | URL = http://www.biomedcentral.com/1476-4598/5/11 }}
</ref>  Like very rule, there are exceptions.
</ref>  Like very rule, there are exceptions.



Revision as of 13:05, 19 April 2015

Cells with a high NC ratio (small cell carcinoma).

Nucleus-to-cytoplasm ratio, also nuclear-cytoplasmic ratio, is the relative size of the nucleus to the cytoplasm. It is commonly abbreviated NC ratio.

High NC ratio is a strong predictor of malignancy.[1] Like very rule, there are exceptions.

High NC ratio in normal cells

  • Lymphocytes.

Low NC ratio in cancer

High NC ratio in cancer

The classic malignant high NC ratio cell is small cell carcinoma, which is in the large small round cell tumour group.

Atypical cells with a normal NC ratio

See also

References

  1. Mehrotra, R.; Gupta, A.; Singh, M.; Ibrahim, R. (2006). "Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions.". Mol Cancer 5: 11. doi:10.1186/1476-4598-5-11. PMID 16556320.