Nucleolus

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The nucleolus (plural nucleoli) is a thingy in the nucleus that may give the pathologist a clue to what they are looking at.

Generally speaking, large nucleoli are uncommon. They are associated with gene transcription activity and are seen in malignancy and reactive conditions.

Macronucleolus

Almost the size of RBC ~ 6-7 micrometers.

Example:

Red nucleolus

Large - can be seen with 10x objective.

Examples:

Large nucleulus

Large - can be seen with 10x objective.

Examples:

Medium-sized nucleolus

Medium - can be seen well with 20x objective.

Examples:

Small

Small - hard to see at 20x objective, seen with 40x objective.

Examples:

Indistinct nucleolus

Not present - cannot see with 40x objective.

Examples:

See also

References

  1. Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 329. ISBN 978-1416054542.