Difference between revisions of "Non-malignant skin disease"

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Non-malignant skin disease (view source)

Revision as of 02:42, 14 October 2013

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→‎Molluscum contagiosum: splitout
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==Molluscum contagiosum==
==Molluscum contagiosum==
*Abbreviated ''MC''.
{{Main|Molluscum contagiosum}}
===General===
*Etiology: caused by ''molluscum contagiosum virus''.
*May be abundant in immune deficient individuals, e.g. [[HIV]]/AIDS.
 
===Gross===
Features:<ref name=Ref_Derm115>{{Ref Derm|115}}</ref>
*Dome-shaped papules, flesh coloured or pearly.
*Usually face or trunk.
*+/-Central umbilication.
**Central depression.
 
DDx - gross:
*[[Skin tag]].
 
Image:
*[http://commons.wikimedia.org/wiki/File:Molluscaklein.jpg Molluscum contagiosum (WC)].
 
===Microscopic===
Features:<ref name=Ref_Derm115>{{Ref Derm 115}}</ref>
*A suprabasilar epidermal lesion consisting of "molluscum bodies" -- in other words "molluscum bodies" are found above the stratum basale +/- extension to the skin surface.
**Molluscum bodies - '''key feature''':
***Large cells with (granular) eosinophilic cytoplasmic inclusions.
****The inclusions usually fill the cytoplasm.
****Inclusions are usually one per cell... but may be multiple.
***Small peripheral nucleus.
*+/-Lymphocytes.
 
Notes:
*Molluscum bodies very vaguely resemble ''[[signet ring cell]]s'' -- but:
**Cytoplasm is eosinophilic and granular.
**Nucleus usually smaller than in signet ring cells.
**''Molluscum bodies'' are only in the epidermis - an uncommon place to find SRCs without finding them elsewhere.
*The granular eosinophilic cytoplasmic inclusions represents accumulated virons.
*Molluscum bodies "grow" toward the surface
 
DDx:
*Nothing really - it is very distinctive.
 
Images:
*[http://commons.wikimedia.org/wiki/File:Molluscum_contagiosum_high_mag.jpg Molluscum contagiosum - high mag. (WC)].
*[http://commons.wikimedia.org/wiki/File:Molluscum_contagiosum_low_mag.jpg Molluscum contagiosum - low magnification (WC)].
*[http://commons.wikimedia.org/wiki/File:Molluscum_contagiosum_1.jpg Molluscum contagiosum (WC)].
 
===Sign out===
<pre>
SKIN LESION ("SKIN TAG"), EXCISION:
- MOLLUSCUM CONTAGIOSUM.
</pre>
 
====Micro====
The section shows fragments of skin with epithelium on three sides. Large suprabasilar cells with eosinophilic intracytoplasmic inclusions (molluscum bodies) and small eccentric nuclei are present, and extend to the skin surface. The epithelium is acanthotic; however, it matures to the surface. There is no significant inflammation.


==Superficial dermal infiltrates==
==Superficial dermal infiltrates==
Michael
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