Difference between revisions of "Nodular hidradenoma"
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'''Nodular hidradenoma''', also known as '''eccrine acrospiroma''',<ref name=pmid18319032>{{Cite journal | last1 = Punia | first1 = RP. | last2 = Garg | first2 = S. | last3 = Bal | first3 = A. | last4 = Mohan | first4 = H. | title = Pigmented nodular hidradenoma masquerading as nodular malignant melanoma. | journal = Dermatol Online J | volume = 14 | issue = 1 | pages = 15 | month = | year = 2008 | doi = | PMID = 18319032 |URL = http://dermatology.cdlib.org/141/case_presentations/hidradenoma/punia.html }}</ref> is a benign adnexal [[skin tumour]]. | |||
==General== | |||
*Benign adnexal tumour.<ref name=pmid9537017>{{Cite journal | last1 = Stratigos | first1 = AJ. | last2 = Olbricht | first2 = S. | last3 = Kwan | first3 = TH. | last4 = Bowers | first4 = KE. | title = Nodular hidradenoma. A report of three cases and review of the literature. | journal = Dermatol Surg | volume = 24 | issue = 3 | pages = 387-91 | month = Mar | year = 1998 | doi = | PMID = 9537017 }}</ref> | |||
==Gross== | |||
Typical locations:<ref name=pmid18319032/> | |||
*Scalp. | |||
*Face. | |||
*Trunk, anterior. | |||
==Microscopic== | |||
Features:<ref name=pmid9537017/> | |||
*Well-circumscribed dermal lesions with: | |||
**Back-to-back nests with a whorled appearance. | |||
**Spaces between cells. | |||
**Nuclei ovoid and centrally placed in the cell. | |||
***No nucleolus. | |||
**Cystic spaces with degenerated cells. | |||
DDx: | |||
*[[Eccrine poroma]]. | |||
*[[Squamous cell carcinoma]].<ref>{{cite journal |authors=Nakazato S, Yanagi T, Inamura Y, Kitamura S, Hata H, Shimizu H |title=A case of nodular hidradenoma of the auricle mimicking squamous cell carcinoma |journal=Eur J Dermatol |volume=26 |issue=4 |pages=409–10 |date=August 2016 |pmid=27350422 |doi=10.1684/ejd.2016.2810 |url=}}</ref> | |||
*[[Glomus tumour]]. | |||
===Images=== | |||
<gallery> | |||
Image:Nodular_hidradenoma_-_low_mag.jpg | Nodular hidradenoma - low mag. (WC/Nephron) | |||
Image:Nodular_hidradenoma_-_intermed_mag.jpg | Nodular hidradenoma - intermed. mag. (WC/Nephron) | |||
Image:Nodular_hidradenoma_-_very_high_mag.jpg | Nodular hidradenoma - very high mag. (WC/Nephron) | |||
</gallery> | |||
==IHC== | |||
Features:<ref name=pmid9537017/> | |||
*CAM5.2 +ve. | |||
*AE1/AE3 +ve. | |||
*EMA +ve. | |||
*S100 -ve. | |||
*Desmin -ve. | |||
==Sign out== | |||
<pre> | |||
Left Thumb Lesion, Excision: | |||
- Hidradenoma. | |||
</pre> | |||
===Micro=== | |||
The sections show an epithelial tumour with squamoid features, mild pleomorphism and whirling, that underlies a benign epidermis. Degenerative changes are present. Rare mitotic figures are seen. | |||
PAS and PASD staining shows PAS-positive diastase-resistant droplets. The tumour is CAM5.2 POSITIVE, S-100 NEGATIVE and SMA NEGATIVE. | |||
==See also== | |||
*[[Skin tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Dermatologic neoplasms]] | |||
Latest revision as of 23:05, 25 November 2020
Nodular hidradenoma, also known as eccrine acrospiroma,[1] is a benign adnexal skin tumour.
General
- Benign adnexal tumour.[2]
Gross
Typical locations:[1]
- Scalp.
- Face.
- Trunk, anterior.
Microscopic
Features:[2]
- Well-circumscribed dermal lesions with:
- Back-to-back nests with a whorled appearance.
- Spaces between cells.
- Nuclei ovoid and centrally placed in the cell.
- No nucleolus.
- Cystic spaces with degenerated cells.
DDx:
Images
Nodular hidradenoma - low mag. (WC/Nephron)
Nodular hidradenoma - intermed. mag. (WC/Nephron)
Nodular hidradenoma - very high mag. (WC/Nephron)
IHC
Features:[2]
- CAM5.2 +ve.
- AE1/AE3 +ve.
- EMA +ve.
- S100 -ve.
- Desmin -ve.
Sign out
Left Thumb Lesion, Excision:
- Hidradenoma.
Micro
The sections show an epithelial tumour with squamoid features, mild pleomorphism and whirling, that underlies a benign epidermis. Degenerative changes are present. Rare mitotic figures are seen.
PAS and PASD staining shows PAS-positive diastase-resistant droplets. The tumour is CAM5.2 POSITIVE, S-100 NEGATIVE and SMA NEGATIVE.
See also
References
- ↑ 1.0 1.1 Punia, RP.; Garg, S.; Bal, A.; Mohan, H. (2008). "Pigmented nodular hidradenoma masquerading as nodular malignant melanoma.". Dermatol Online J 14 (1): 15. PMID 18319032.
- ↑ 2.0 2.1 2.2 Stratigos, AJ.; Olbricht, S.; Kwan, TH.; Bowers, KE. (Mar 1998). "Nodular hidradenoma. A report of three cases and review of the literature.". Dermatol Surg 24 (3): 387-91. PMID 9537017.
- ↑ Nakazato S, Yanagi T, Inamura Y, Kitamura S, Hata H, Shimizu H (August 2016). "A case of nodular hidradenoma of the auricle mimicking squamous cell carcinoma". Eur J Dermatol 26 (4): 409–10. doi:10.1684/ejd.2016.2810. PMID 27350422.