Nipple adenoma

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Nipple adenoma
Diagnosis in short

LM proliferation of epithelial and myoepithelial elements that extends into the breast stroma; not encapsulated; lacks true fibrovascular cores, +/-focal necrosis
LM DDx intraductal papilloma
Site breast - nipple

Prevalence uncommon
Prognosis benign
Clin. DDx Paget's disease of the breast

Nipple adenoma is a benign pathology of the breast.

It is also known as nipple duct adenoma, nipple adenoma of breast, adenoma of the nipple and florid papillomatosis of the nipple.[1]

General

  • Rare.
  • Reported in men.[1]

Clinical DDx:

Microscopic

Features:

  • Proliferation of epithelial and myoepithelial elements that extends into the breast stroma.[3]

Notes:

  • Not encapsulated.[3]
  • Lacks true fibrovascular cores.[4]
  • Focal necrosis may be present.[5]

DDx:

  • Intraductal papilloma.
    • Found within the duct not the stroma.
    • Often deeper - one should not see skin in the histologic section.

Images

www:

See also

References

  1. 1.0 1.1 Boutayeb, S.; Benomar, S.; Sbitti, Y.; Harroudi, T.; Hassam, B.; Errihani, H. (2012). "Nipple adenoma in a man: An unusual case report.". Int J Surg Case Rep 3 (5): 190-2. doi:10.1016/j.ijscr.2011.05.008. PMID 22342578.
  2. HANDLEY, RS.; THACKRAY, AC. (Jun 1962). "Adenoma of nipple.". Br J Cancer 16: 187-94. PMC 2070922. PMID 13904317. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2070922/?tool=pubmed.
  3. 3.0 3.1 "Adenoma of Nipple.". Br Med J 1 (5330): 563. Mar 1963. PMC 2123505. PMID 20789667. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2123505/?page=1.
  4. URL: http://surgpathcriteria.stanford.edu/breast/nippleadenoma/printable.html. Accessed on: 6 August 2011.
  5. Lefkowitch, Jay H. (2006). Anatomic Pathology Board Review (1st ed.). Saunders. pp. 307 Q16. ISBN 978-1416025887.