Difference between revisions of "Neutrophil"

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[[Image:Neutrophils.jpg|thumb|right|Neutrophils on a blood film.]]
The '''neutrophil''', [[AKA]] '''polymorphonucleocyte''' or '''PMN''' is a white blood cell.  It is often seen in the context of acute inflammation.
The '''neutrophil''', [[AKA]] '''polymorphonucleocyte''' or '''PMN''' is a white blood cell.  It is often seen in the context of acute inflammation.
==Histology==
*Little dots = the multilobular nucleus - '''key feature'''.
*Neutrophils are often found with friends, i.e. lymphocytes, plasma cells.
DDx of little dots:
*Nuclear debris - apoptotic cell.
**Apoptotic cell -- has nuclear condensation (pyknosis), eosinophilic cytoplasm.
Notes:
*You find PMNs by their nucleus; on a histologic section don't bother looking for the cell membrane (they are usually impossible to see).
*A collection of PMNs... think about ''[[necrosis]]'' and ''abscess''.


==Pathology==
==Pathology==
Hypersegmentation = megaloblastic anemia.<ref name=Ref_Klatt63>{{Ref Klatt|63}}</ref>
Hypersegmentation = megaloblastic [[anemia]].<ref name=Ref_Klatt63>{{Ref Klatt|63}}</ref>


==See also==
==See also==
*[[Basics]].
*[[Basics]].
*[[Dysgranulopoiesis]].
*[[Red blood cell]].
*[[Chronic granulomatous disease]] - caused by neutrophil dysfunction.
*[[Eosinophil]].
*[[Auer rods]].


==References==
==References==

Latest revision as of 00:08, 28 July 2015

Neutrophils on a blood film.

The neutrophil, AKA polymorphonucleocyte or PMN is a white blood cell. It is often seen in the context of acute inflammation.

Histology

  • Little dots = the multilobular nucleus - key feature.
  • Neutrophils are often found with friends, i.e. lymphocytes, plasma cells.

DDx of little dots:

  • Nuclear debris - apoptotic cell.
    • Apoptotic cell -- has nuclear condensation (pyknosis), eosinophilic cytoplasm.

Notes:

  • You find PMNs by their nucleus; on a histologic section don't bother looking for the cell membrane (they are usually impossible to see).
  • A collection of PMNs... think about necrosis and abscess.

Pathology

Hypersegmentation = megaloblastic anemia.[1]

See also

References

  1. Klatt, Edward C. (2006). Robbins and Cotran Atlas of Pathology (1st ed.). Saunders. pp. 63. ISBN 978-1416002741.