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Difference between revisions of "Neuropathology"
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→Table of inclusions: wikify
(→Histopathology: re-arr, +red nuclei) |
(→Table of inclusions: wikify) |
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| Cowdry type 1<br>AKA Cowdry type A | | Cowdry type 1<br>AKA Cowdry type A | ||
| eosinophilic & round + halo | | eosinophilic & round + halo | ||
| herpes simplex virus | | [[herpes simplex virus]] | ||
| can be confused with <br>Lewy body, Marinesco body | | can be confused with <br>Lewy body, Marinesco body | ||
| ?Image | | ?Image | ||
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| Lewy body | | Lewy body | ||
| round cytoplasmic eosinophilic<br> body +/- pale halo | | round cytoplasmic eosinophilic<br> body +/- pale halo | ||
| | | [[Parkinson disease]], dementia with Lewy bodies | ||
| morphology dependent on <br>location in brain; +ve for alpha-synuclein, <br>alpha-B crystallin, ubiquitin | | morphology dependent on <br>location in brain; +ve for alpha-synuclein, <br>alpha-B crystallin, ubiquitin | ||
| [http://commons.wikimedia.org/wiki/File:Lewy_Koerperchen.JPG], [http://firstaidteam.com/usmlerximages/v/USMLERxLewy+bodies.gif.html] | | [http://commons.wikimedia.org/wiki/File:Lewy_Koerperchen.JPG], [http://firstaidteam.com/usmlerximages/v/USMLERxLewy+bodies.gif.html] | ||
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| Hirano body | | Hirano body | ||
| concentric calcification/rod-shaped bright eosinophilic; overlap edge of neuron | | concentric calcification/rod-shaped bright eosinophilic; overlap edge of neuron | ||
| Alzheimer | | Alzheimer disease, Pick disease<ref name=Ref_MBNP5>{{Ref MBNP|5}}</ref> | ||
| actin crystals, may look like capillaries; location: CA1 of hippocampus | | actin crystals, may look like capillaries; location: CA1 of hippocampus | ||
| [http://faculty.washington.edu/alexbert/MEDEX/Fall/adhirano.jpg]<ref name=pakmednet>URL: [http://www.pakmed.net/academic/age/alz/alz030.htm http://www.pakmed.net/academic/age/alz/alz030.htm]. Accessed on: 12 November 2010.</ref> | | [http://faculty.washington.edu/alexbert/MEDEX/Fall/adhirano.jpg]<ref name=pakmednet>URL: [http://www.pakmed.net/academic/age/alz/alz030.htm http://www.pakmed.net/academic/age/alz/alz030.htm]. Accessed on: 12 November 2010.</ref> | ||
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| Granulovacuolar degeneration | | Granulovacuolar degeneration | ||
| cytoplasmic vacuoles 4-5 micrometers | | cytoplasmic vacuoles 4-5 micrometers | ||
| ageing, Alzheimer's disease, <br>Pick's disease | | ageing, [[Alzheimer's disease]], <br>Pick's disease | ||
| main found in Ammon horn<ref name=Ref_MBNP5>{{Ref MBNP|5}}</ref> | | main found in Ammon horn<ref name=Ref_MBNP5>{{Ref MBNP|5}}</ref> | ||
| [http://faculty.washington.edu/alexbert/MEDEX/Fall/adgvd.jpg]<ref name=alexbert>URL: [http://faculty.washington.edu/alexbert/MEDEX/Fall/NeuroPath_Obj.htm http://faculty.washington.edu/alexbert/MEDEX/Fall/NeuroPath_Obj.htm]. Accessed on: 13 November 2010.</ref> | | [http://faculty.washington.edu/alexbert/MEDEX/Fall/adgvd.jpg]<ref name=alexbert>URL: [http://faculty.washington.edu/alexbert/MEDEX/Fall/NeuroPath_Obj.htm http://faculty.washington.edu/alexbert/MEDEX/Fall/NeuroPath_Obj.htm]. Accessed on: 13 November 2010.</ref> | ||
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| Pick bodies | | Pick bodies | ||
| round, homogenous, intracytoplasmic, ~10 micrometers | | round, homogenous, intracytoplasmic, ~10 micrometers | ||
| Pick's disease | | [[Pick's disease]] | ||
| pyramidal neurons, dentate <br>granule cells (hippocampus); +ve for tau, tubulin, ubiquitin | | pyramidal neurons, dentate <br>granule cells (hippocampus); +ve for tau, tubulin, ubiquitin | ||
| [http://s212.photobucket.com/albums/cc74/cat_at_uw/Osler%20-%20Neuropath/?action=view¤t=Picks60x.jpg&mediafilter=images] | | [http://s212.photobucket.com/albums/cc74/cat_at_uw/Osler%20-%20Neuropath/?action=view¤t=Picks60x.jpg&mediafilter=images] | ||
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| Bunina body | | Bunina body | ||
| size of Nissl granules, eosinophilic | | size of Nissl granules, eosinophilic | ||
| ALS | | [[amyotrophic lateral sclerosis]] (ALS) | ||
| EM: membrane-bound bodies; ubiquitin +ve | | EM: membrane-bound bodies; ubiquitin +ve | ||
| [http://pathol.umin.ac.jp/gakubu/exam/2006jpg/19.jpg] | | [http://pathol.umin.ac.jp/gakubu/exam/2006jpg/19.jpg] | ||