Difference between revisions of "Neuroendocrine neoplasms"

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Neuroendocrine neoplasms (view source)

Revision as of 18:32, 29 March 2012

223 bytes added ,  18:32, 29 March 2012
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===Stomach===
===Stomach===
Divided into four types:<ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/StomachNET_11protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/StomachNET_11protocol.pdf]. Accessed on: 29 March 2012.</ref>
Divided into four types:<ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/StomachNET_11protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/StomachNET_11protocol.pdf]. Accessed on: 29 March 2012.</ref>
*Type I.
{| class="wikitable sortable"
**Chronic atrophic gastritis - usually autoimmune gastritis.
!Tumour type
**Hypochlorhydia.
!Relative prevalence
**Good prognosis.
!Multifocality
*Type II.
!Size
**[[Zollinger-Ellison syndrome]].
!Typical location
***Often [[MEN 1]] - may be multifocal.
!Clinical
**Hyperchlorhydia, pancreatic ''or'' duodenal NET secreting gastrin (gastrinoma).
!Other
**Rare.
!Histology
**Poor prognosis.
|-
*Type III.
|Type 1
**Usually solitary.
| ~75%
**Sporadic.
| yes
**Normal gastrin.
| small (5-10 mm)
**Aggressive behaviour if > 2.0 cm.
| body
*Type IV.
| benign typically, female:male ~ 4:1, 50-60 years
**Elevated gastrin due to parietal cell dysfunction.
| chronic atrophic gastritis - usu. autoimmune
**Extremely rare.
| WDNET, WDNEC
**Usually metastases at time of diagnosis.
|-
|Type 2
| rare
| yes
| small ~15 mm
| body
| aggressive, ~50 years old
| assoc. [[MEN I]], hyperchlorhydia
| WDNEC, WDNET
|-
|Type 3
| 10-15%
| no
| small and large
| variable location
| males > females, >2.0 cm tumours aggressive
| normal gastrin levels
| WDNET
|-
|Type 4
| extremely rare
| no
| large
| variable location
| males > females, mets usu. at time of Dx
| elevated gastrin d/t parietal cell dysfunction
| PDNEC
|-
|}


===Pancreatic===
===Pancreatic===
Michael
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