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Difference between revisions of "Neurodegenerative diseases"
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* Lewy bodies and extracellular pigment in neuromelanin-containing nuclei (SN, LC, DVN) -> PD. | * Lewy bodies and extracellular pigment in neuromelanin-containing nuclei (SN, LC, DVN) -> PD. | ||
* Spongiform vacuolation in the neuropil (seen in Prion disease). | * Spongiform vacuolation in the neuropil (seen in Prion disease and FTLD-TDP). | ||
* Neurofibrillar tangles (pyramidal layer of dentate gyrus). | |||
* Granulovacuolar degeneration (granules within cytoplasmic vacuoles, mainly in the hippocampal pyramidal neurons, seen in AD). | |||
* Cores of amyloid plaqyes. | |||
* Cotton wool plaques (seen in familiar AD). | * Cotton wool plaques (seen in familiar AD). | ||
* Pick cells (balloned neurons in frontal cortex). | |||
* Pick bodies (granular layer of dentate gyrus). | |||
* Extensive astrogliosis (striatonigral degeneration, hepatic encephalopathy). | |||
* Corpora amylacea in the cornu ammonis may be increased in neurodegenerative diseases. <ref>{{Cite journal | last1 = Kovacs | first1 = GG. | last2 = Risser | first2 = D. | title = Clinical Neuropathology image 6-2014: Corpora amylacea replacing cornu ammonis (CACA). | journal = Clin Neuropathol | volume = 33 | issue = 6 | pages = 378-9 | month = | year = | doi = | PMID = 25343241 }}</ref> | * Corpora amylacea in the cornu ammonis may be increased in neurodegenerative diseases. <ref>{{Cite journal | last1 = Kovacs | first1 = GG. | last2 = Risser | first2 = D. | title = Clinical Neuropathology image 6-2014: Corpora amylacea replacing cornu ammonis (CACA). | journal = Clin Neuropathol | volume = 33 | issue = 6 | pages = 378-9 | month = | year = | doi = | PMID = 25343241 }}</ref> | ||